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AVAILABLE MUTANTS (ISOLATED)
 変異体 To English >>
 
Record No. 331
対立遺伝子 tm331
Sequence Name VZK822L.1
CGC Name fat-6
Worm Base 対立遺伝子 tm331
CGC Name fat-6
Sequence VZK822L.1
表現型 homozygous viable. Dr. H. Arai: WT (Brood size, embryonic lethality, larval lehtality, growth rate), Dr. G. Hermann: wild-type gut granules. Dr. K. Sakamoto: J. Biochem 144, 149 (2008). Dr. J. Watts & Dr. J. Browse: PLoS Genetics 2, e108 (2006), Genetics 176, 865 (2007).
変異部位 6436/6437-AATACCGCAATAGGGTTCACTTAAAAACGAATGTTGTAGAATGAAAAAAGAAATAGAAAAGAAGATAAGTGATGTTGAGCATAAAACATAAGATGTGTTGAAAAAGAAAGAAAAACGGAAAATTTGATCAAATTTGAAACGTATCTTTTCCTCTTCTCCCTTTCTTCTTACTTCCGTTCTTCTCTTACTTTCAATCCAATCATGCTCCTTGTCTTCTCATAATTTTATTGCTTTTTGTCTCCTCTTTTCTCGCCTTCTGCAACACAAAGTGCAAACCTAAATTCCATTTAGTTTTCTTACACAAAATGATTGAAAAGTAAATGTTTTATGATGAAAAGTATGAGCCATCATTCATCTGATCATCCATCTCTTTTGTTTAAATATCAATTTTTTAGATTGTGAAGACATGTGAGCAACTTGAAACTGAT-7668/7669 (1232 bp deletion + 428 bp insertion)
染色体 IV
遺伝子構造 complement(join(5893..6172,6281..6442,6498..6834, 7133..7253,7623..7742)
マップポジション 5.39
バランサ
バランサマップポジション
プライマー配列 ExtFwd:ACTCTTGGCACAAAACGGCG,IntFwd:GTTCCCAGTTTTTGACGTGT,IntRev:AAAGGGCCTTGCGTAGTGTA,ExtRev:GATATCAGACGACGGGCAGG
変異体送付先
寄託者 Dr. S. Mitani/NBRP
文献  論文登録
Dancy BC, Chen SW, Drechsler R, Gafken PR, Olsen CP.
13C- and 15N-Labeling Strategies Combined with Mass Spectrometry Comprehensively Quantify Phospholipid Dynamics in C. elegans.
PLoS ONE 2015 10(11) e0141850 
[ PubMed ID = 26528916 ] [ RRCの論文情報 ]

Liu Z, Shi H, Szymczak LC, Aydin T, Yun S, Constas K, Schaeffer A, Ranjan S, Kubba S, Alam E, McMahon DE, He J, Shwartz N, Tian C, Plavskin Y, Lindy A, Dad NA, Sheth S, Amin NM, Zimmerman S, Liu D, Schwarz EM, Smith H, Krause MW, Liu J.
Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids.
PLoS Genet. 2015 11(5) e1005221 
[ PubMed ID = 25978409 ] [ RRCの論文情報 ]

Garcia AM, Ladage ML, Dumesnil DR, Zaman K, Shulaev V, Azad RK, Padilla PA.
Glucose induces sensitivity to oxygen deprivation and modulates insulin/IGF-1 signaling and lipid biosynthesis in Caenorhabditis elegans.
Genetics 2015 200(1) 167-84 
[ PubMed ID = 25762526 ] [ RRCの論文情報 ]

Wang P, Liu B, Zhang D, Belew MY, Tissenbaum HA, Cheng JX.
Imaging lipid metabolism in live Caenorhabditis elegans using fingerprint vibrations.
Angew. Chem. Int. Ed. Engl. 2014 53(44) 11787-92 
[ PubMed ID = 25195517 ] [ RRCの論文情報 ]

Vásquez V, Krieg M, Lockhead D, Goodman MB.
Phospholipids that contain polyunsaturated fatty acids enhance neuronal cell mechanics and touch sensation.
Cell Rep. 2014 6(1) 70-80 
[ PubMed ID = 24388754 ] [ RRCの論文情報 ]

Tserevelakis GJ, Megalou EV, Filippidis G, Petanidou B, Fotakis C, Tavernarakis N.
Label-free imaging of lipid depositions in C. elegans using third-harmonic generation microscopy.
PLoS ONE 2014 9(1) e84431 
[ PubMed ID = 24392137 ] [ RRCの論文情報 ]

Shi X, Li J, Zou X, Greggain J, Rødkær SV, Færgeman NJ, Liang B, Watts JL.
Regulation of lipid droplet size and phospholipid composition by stearoyl-CoA desaturase.
J Lipid Res. 2013 54(9) 2504-14 
[ PubMed ID = 23787165 ] [ RRCの論文情報 ]

Goh GY, Martelli KL, Parhar KS, Kwong AW, Wong MA, Mah A, Hou NS, Taubert S.
The conserved Mediator subunit MDT-15 is required for oxidative stress responses in Caenorhabditis elegans.
Aging Cell 2013 13(1) 70-9 
[ PubMed ID = 23957350 ] [ RRCの論文情報 ]

Erkut C, Vasilj A, Boland S, Habermann B, Shevchenko A, Kurzchalia TV.
Molecular strategies of the Caenorhabditis elegans dauer larva to survive extreme desiccation.
PLoS ONE 2013 8(12) e82473 
[ PubMed ID = 24324795 ] [ RRCの論文情報 ]

Castro C, Sar F, Shaw WR, Mishima M, Miska EA, Griffin JL.
A metabolomic strategy defines the regulation of lipid content and global metabolism by Δ9 desaturases in Caenorhabditis elegans.
BMC Genomics 2012 13 36 
[ PubMed ID = 22264337 ] [ RRCの論文情報 ]

Goudeau J, Bellemin S, Toselli-Mollereau E, Shamalnasab M, Chen Y, Aguilaniu H.
Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans.
PLoS Biol. 2011 9(3) e1000599 
[ PubMed ID = 21423649 ] [ RRCの論文情報 ]

Savory FR, Sait SM, Hope IA.
DAF-16 and Δ9 desaturase genes promote cold tolerance in long-lived Caenorhabditis elegans age-1 mutants.
PLoS ONE 2011 6(9) e24550 
[ PubMed ID = 21931751 ] [ RRCの論文情報 ]

Horikawa M, Sakamoto K.
Polyunsaturated fatty acids are involved in regulatory mechanism of fatty acid homeostasis via daf-2/insulin signaling in Caenorhabditis elegans.
Mol. Cell. Endocrinol. 2010 323(2) 183-92 
[ PubMed ID = 20226839 ] [ RRCの論文情報 ]

Le TT, Duren HM, Slipchenko MN, Hu CD, Cheng JX.
Label-free quantitative analysis of lipid metabolism in living Caenorhabditis elegans.
J Lipid Res. 2010 51(3) 672-7 
[ PubMed ID = 19776402 ] [ RRCの論文情報 ]

Liang B, Ferguson K, Kadyk L, Watts JL.
The role of nuclear receptor NHR-64 in fat storage regulation in Caenorhabditis elegans.
PLoS ONE 2010 5(3) e9869 
[ PubMed ID = 20360843 ] [ RRCの論文情報 ]

Nandakumar M, Tan MW.
Gamma-linolenic and stearidonic acids are required for basal immunity in Caenorhabditis elegans through their effects on p38 MAP kinase activity.
PLoS Genet. 2008 4(11) e1000273 
[ PubMed ID = 19023415 ] [ RRCの論文情報 ]

Currie E, King B, Lawrenson AL, Schroeder LK, Kershner AM, Hermann GJ.
Role of the Caenorhabditis elegans multidrug resistance gene, mrp-4, in gut granule differentiation.
Genetics 2007 177(3) 1569-82 
[ PubMed ID = 17947407 ] [ RRCの論文情報 ]

Brock TJ, Browse J, Watts JL.
Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans.
Genetics 2007 176(2) 865-75 
[ PubMed ID = 17435249 ] [ RRCの論文情報 ]

Brock TJ, Browse J, Watts JL.
Genetic regulation of unsaturated fatty acid composition in C. elegans.
PLoS Genet. 2006 2(7) e108 
[ PubMed ID = 16839188 ] [ RRCの論文情報 ]