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AVAILABLE MUTANTS (ISOLATED)
 変異体 To English >>
 
Record No. 3100
対立遺伝子 tm3100
Sequence Name C09G5.8
CGC Name C09G5.8
Worm Base 対立遺伝子 tm3100
CGC Name C09G5.8
Sequence C09G5.8
表現型 homozygous viable. Dr. O. Blacque: Dyf (+). Dr. K. Ashrafi: non-Gro.
変異部位 26722/26723-27262/27263 (540 bp deletion)
染色体 II
遺伝子構造 join(24056..24159, 24467..24576, 24694..24835, 24885..24951, 25049..25173, 26121..26246, 26614..26913, 26993..27125, 27180..27547, 27861..28121, 29490..29688, Z46792.1:109..204, Z46792.1:256..426, Z46792.1:664..882, Z46792.1:1065..1283, Z46792.1:2577..2846, Z46792.1:3000..3449, Z46792.1:3497..3600, Z46792.1:3647..4197, Z46792.1:4282..4608, Z46792.1:5030..5200, Z46792.1:5252..5334)
マップポジション 2.84
バランサ
バランサマップポジション
プライマー配列 ExtRev:GATCTTCACGACGTCTGTGT,IntRev:ATACTTTCCCGTGCTCCGTA,IntFwd:AATTCCAGGGTATCCGCAAG,ExtFwd:CGGCATAGGGAGAGATAATA
変異体送付先
寄託者 Dr. S. Mitani/NBRP
文献  論文登録
Jensen VL, Li C, Bowie RV, Clarke L, Mohan S, Blacque OE, Leroux MR.
Formation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP2 ciliary abundance.
EMBO J. 2015 34(20) 2537-56 
[ PubMed ID = 26392567 ] [ RRCの論文情報 ]

Roberson EC, Dowdle WE, Ozanturk A, Garcia-Gonzalo FR, Li C, Halbritter J, Elkhartoufi N, Porath JD, Cope H, Ashley-Koch A, Gregory S, Thomas S, Sayer JA, Saunier S, Otto EA, Katsanis N, Davis EE, Attié-Bitach T, Hildebrandt F, Leroux MR, Reiter JF.
TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone.
J Cell Biol. 2015 209(1) 129-42 
[ PubMed ID = 25869670 ] [ RRCの論文情報 ]

Nguyen PA, Liou W, Hall DH, Leroux MR.
Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron.
J Cell Sci. 2014 127(Pt 24) 5317-30 
[ PubMed ID = 25335890 ] [ RRCの論文情報 ]

Brear AG, Yoon J, Wojtyniak M, Sengupta P.
Diverse cell type-specific mechanisms localize G protein-coupled receptors to Caenorhabditis elegans sensory cilia.
Genetics 2014 197(2) 667-84 
[ PubMed ID = 24646679 ] [ RRCの論文情報 ]

Cevik S, Sanders AA, Van Wijk E, Boldt K, Clarke L, van Reeuwijk J, Hori Y, Horn N, Hetterschijt L, Wdowicz A, Mullins A, Kida K, Kaplan OI, van Beersum SE, Man Wu K, Letteboer SJ, Mans DA, Katada T, Kontani K, Ueffing M, Roepman R, Kremer H, Blacque OE.
Active transport and diffusion barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an Inv-like ciliary membrane subdomain.
PLoS Genet. 2013 9(12) e1003977 
[ PubMed ID = 24339792 ] [ RRCの論文情報 ]

Huang L, Szymanska K, Jensen VL, Janecke AR, Innes AM, Davis EE, Frosk P, Li C, Willer JR, Chodirker BN, Greenberg CR, McLeod DR, Bernier FP, Chudley AE, Müller T, Shboul M, Logan CV, Loucks CM, Beaulieu CL, Bowie RV, Bell SM, Adkins J, Zuniga FI, Ross KD, Wang J, Ban MR, Becker C, Nürnberg P, Douglas S, Craft CM, Akimenko MA, Hegele RA, Ober C, Utermann G, Bolz HJ, Bulman DE, Katsanis N, Blacque OE, Doherty D, Parboosingh JS, Leroux MR, Johnson CA, Boycott KM.
TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone.
Am. J. Hum. Genet. 2011 89(6) 713-30 
[ PubMed ID = 22152675 ] [ RRCの論文情報 ]

Liu L, Zhang M, Xia Z, Xu P, Chen L, Xu T.
Caenorhabditis elegans ciliary protein NPHP-8, the homologue of human RPGRIP1L, is required for ciliogenesis and chemosensation.
Biochem. Biophys. Res. Commun. 2011 410(3) 626-31 
[ PubMed ID = 21689635 ] [ RRCの論文情報 ]

Williams CL, Li C, Kida K, Inglis PN, Mohan S, Semenec L, Bialas NJ, Stupay RM, Chen N, Blacque OE, Yoder BK, Leroux MR.
MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis.
J Cell Biol. 2011 192(6) 1023-41 
[ PubMed ID = 21422230 ] [ RRCの論文情報 ]