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Record No. 3036
対立遺伝子 tm3036
Sequence Name F13B10.1b
CGC Name tir-1
Worm Base 対立遺伝子 tm3036
CGC Name tir-1
Sequence F13B10.1b
表現型 homozygous viable. Dr. J. Ewbank: Curr. Biol. 18, 481 (2008).
変異部位 2308/2309-2577/2578 (269 bp deletion)
染色体 III
遺伝子構造 complement(join(1550..1635, 1693..1810, 1967..3001, 4342..4863))
マップポジション -4.25
バランサ
バランサマップポジション
プライマー配列 :CCATACATGCATCCTGATAG,ExtRev:AAGTGGCCTCCTCTCCAGAC,IntFwd:GCACCCAATCCTCACAGTTA,IntRev:AAGTTCGCCTCCGAAGCACT
変異体送付先
寄託者 Dr. S. Mitani/NBRP
文献  論文登録
Alqadah A, Hsieh YW, Vidal B, Chang C, Hobert O, Chuang CF.
Postmitotic diversification of olfactory neuron types is mediated by differential activities of the HMG-box transcription factor SOX-2.
EMBO J. 2015 34(20) 2574-89 
[ PubMed ID = 26341465 ] [ RRCの論文情報 ]

Ding W, Smulan LJ, Hou NS, Taubert S, Watts JL, Walker AK.
s-Adenosylmethionine Levels Govern Innate Immunity through Distinct Methylation-Dependent Pathways.
Cell Metab. 2015 22(4) 633-45 
[ PubMed ID = 26321661 ] [ RRCの論文情報 ]

Ren Z, Ambros VR.
Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress.
Proc. Natl. Acad. Sci. U.S.A. 2015 112(18) E2366-75 
[ PubMed ID = 25897023 ] [ RRCの論文情報 ]

Zhang Y, Li W, Li L, Li Y, Fu R, Zhu Y, Li J, Zhou Y, Xiong S, Zhang H.
Structural damage in the C. elegans epidermis causes release of STA-2 and induction of an innate immune response.
Immunity 2015 42(2) 309-20 
[ PubMed ID = 25692704 ] [ RRCの論文情報 ]

Xu S, Chisholm AD.
C. elegans epidermal wounding induces a mitochondrial ROS burst that promotes wound repair.
Dev. Cell 2014 31(1) 48-60 
[ PubMed ID = 25313960 ] [ RRCの論文情報 ]

Zugasti O, Bose N, Squiban B, Belougne J, Kurz CL, Schroeder FC, Pujol N, Ewbank JJ.
Activation of a G protein-coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans.
Nat. Immunol. 2014 15(9) 833-8 
[ PubMed ID = 25086774 ] [ RRCの論文情報 ]

Crook-McMahon HM, Oláhová M, Button EL, Winter JJ, Veal EA.
Genome-wide screening identifies new genes required for stress-induced phase 2 detoxification gene expression in animals.
BMC Biol. 2014 12 64 
[ PubMed ID = 25204677 ] [ RRCの論文情報 ]

Inoue A, Sawatari E, Hisamoto N, Kitazono T, Teramoto T, Fujiwara M, Matsumoto K, Ishihara T.
Forgetting in C. elegans is accelerated by neuronal communication via the TIR-1/JNK-1 pathway.
Cell Rep 2013 3(3) 808-19 
[ PubMed ID = 23523351 ] [ RRCの論文情報 ]

Xie Y, Moussaif M, Choi S, Xu L, Sze JY.
RFX transcription factor DAF-19 regulates 5-HT and innate immune responses to pathogenic bacteria in Caenorhabditis elegans.
PLoS Genet. 2013 9(3) e1003324 
[ PubMed ID = 23505381 ] [ RRCの論文情報 ]

Hsieh YW, Chang C, Chuang CF.
The microRNA mir-71 inhibits calcium signaling by targeting the TIR-1/Sarm1 adaptor protein to control stochastic L/R neuronal asymmetry in C. elegans.
PLoS Genet. 2012 8(8) e1002864 
[ PubMed ID = 22876200 ] [ RRCの論文情報 ]

Labed SA, Omi S, Gut M, Ewbank JJ, Pujol N.
The pseudokinase NIPI-4 is a novel regulator of antimicrobial peptide gene expression.
PLoS ONE 2012 7(3) e33887 
[ PubMed ID = 22470487 ] [ RRCの論文情報 ]

Xu S, Chisholm AD.
A Gαq-Ca²⁺ signaling pathway promotes actin-mediated epidermal wound closure in C. elegans.
Curr. Biol. 2011 21(23) 1960-7 
[ PubMed ID = 22100061 ] [ RRCの論文情報 ]

Chang C, Hsieh YW, Lesch BJ, Bargmann CI, Chuang CF.
Microtubule-based localization of a synaptic calcium-signaling complex is required for left-right neuronal asymmetry in C. elegans.
Development 2011 138(16) 3509-18 
[ PubMed ID = 21771813 ] [ RRCの論文情報 ]

Hayakawa T, Kato K, Hayakawa R, Hisamoto N, Matsumoto K, Takeda K, Ichijo H.
Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins.
Genetics 2011 187(3) 785-92 
[ PubMed ID = 21212236 ] [ RRCの論文情報 ]

Lee KZ, Kniazeva M, Han M, Pujol N, Ewbank JJ.
The fatty acid synthase fasn-1 acts upstream of WNK and Ste20/GCK-VI kinases to modulate antimicrobial peptide expression in C. elegans epidermis.
Virulence 2010 1(3) 113-22 
[ PubMed ID = 21178429 ] [ RRCの論文情報 ]

Shivers RP, Kooistra T, Chu SW, Pagano DJ, Kim DH.
Tissue-specific activities of an immune signaling module regulate physiological responses to pathogenic and nutritional bacteria in C. elegans.
Cell Host Microbe 2009 6(4) 321-30 
[ PubMed ID = 19837372 ] [ RRCの論文情報 ]

Ziegler K, Kurz CL, Cypowyj S, Couillault C, Pophillat M, Pujol N, Ewbank JJ.
Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade.
Cell Host Microbe 2009 5(4) 341-52 
[ PubMed ID = 19380113 ] [ RRCの論文情報 ]

Tong A, Lynn G, Ngo V, Wong D, Moseley SL, Ewbank JJ, Goncharov A, Wu YC, Pujol N, Chisholm AD.
Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase.
Proc. Natl. Acad. Sci. U.S.A. 2009 106(5) 1457-61 
[ PubMed ID = 19164535 ] [ RRCの論文情報 ]

Pujol N, Zugasti O, Wong D, Couillault C, Kurz CL, Schulenburg H, Ewbank JJ.
Anti-fungal innate immunity in C. elegans is enhanced by evolutionary diversification of antimicrobial peptides.
PLoS Pathog. 2008 4(7) e1000105 
[ PubMed ID = 18636113 ] [ RRCの論文情報 ]

Pujol N, Cypowyj S, Ziegler K, Millet A, Astrain A, Goncharov A, Jin Y, Chisholm AD, Ewbank JJ.
Distinct innate immune responses to infection and wounding in the C. elegans epidermis.
Curr. Biol. 2008 18(7) 481-9 
[ PubMed ID = 18394898 ] [ RRCの論文情報 ]