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AVAILABLE MUTANTS (ISOLATED)
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Record No. 1944
対立遺伝子 tm1944
Sequence Name PAR2.3
CGC Name aak-1
Worm Base 対立遺伝子 tm1944
CGC Name aak-1
Sequence PAR2.3
表現型 homozygous viable. Dr. L. Avery: mildly sensitive to long-term starvation (e.g. 15 days of starvation as L1). Dr. K. Ashrafi: normal Nile Red staining.
変異部位 5139/5140-5757/5758 (618 bp deletion)
染色体 III
遺伝子構造 complement(join(2399..2524, 2582..2670, 3146..3280, 3628..4180, 4408..4458, 4608..4816, 4865..5126, 5406..5731, 6094..6211)
マップポジション -0.06
バランサ
バランサマップポジション
プライマー配列 ExtRev:ACTCAATCGCGTGACCTCCT,ExtFwd:CGAACCTCTGCAACACTCTG,IntFwd:TCGATACGGAACCAACTGTG,IntRev:GTGACCTCCTCAGACCCTAT
変異体送付先
寄託者 Dr. S. Mitani/NBRP
文献  論文登録
Seidel HS, Kimble J.
Cell-cycle quiescence maintains Caenorhabditis elegans germline stem cells independent of GLP-1/Notch.
Elife 2015 4  
[ PubMed ID = 26551561 ] [ RRCの論文情報 ]

Possik E, Ajisebutu A, Manteghi S, Gingras MC, Vijayaraghavan T, Flamand M, Coull B, Schmeisser K, Duchaine T, van Steensel M, Hall DH, Pause A.
FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores.
PLoS Genet. 2015 11(10) e1005520 
[ PubMed ID = 26439621 ] [ RRCの論文情報 ]

Xie M, Roy R.
The Causative Gene in Chanarian Dorfman Syndrome Regulates Lipid Droplet Homeostasis in C. elegans.
PLoS Genet. 2015 11(6) e1005284 
[ PubMed ID = 26083785 ] [ RRCの論文情報 ]

Lee JH, Kong J, Jang JY, Han JS, Ji Y, Lee J, Kim JB.
Lipid droplet protein LID-1 mediates ATGL-1-dependent lipolysis during fasting in Caenorhabditis elegans.
Mol. Cell. Biol. 2014 34(22) 4165-76 
[ PubMed ID = 25202121 ] [ RRCの論文情報 ]

Cunningham KA, Bouagnon AD, Barros AG, Lin L, Malard L, Romano-Silva MA, Ashrafi K.
Loss of a neural AMP-activated kinase mimics the effects of elevated serotonin on fat, movement, and hormonal secretions.
PLoS Genet. 2014 10(6) e1004394 
[ PubMed ID = 24921650 ] [ RRCの論文情報 ]

Possik E, Jalali Z, Nouët Y, Yan M, Gingras MC, Schmeisser K, Panaite L, Dupuy F, Kharitidi D, Chotard L, Jones RG, Hall DH, Pause A.
Folliculin regulates ampk-dependent autophagy and metabolic stress survival.
PLoS Genet. 2014 10(4) e1004273 
[ PubMed ID = 24763318 ] [ RRCの論文情報 ]

Hubert T, Wu Z, Chisholm AD, Jin Y.
S6 kinase inhibits intrinsic axon regeneration capacity via AMP kinase in Caenorhabditis elegans.
J Neurosci. 2014 34(3) 758-63 
[ PubMed ID = 24431434 ] [ RRCの論文情報 ]

Schiavi A, Torgovnick A, Kell A, Megalou E, Castelein N, Guccini I, Marzocchella L, Gelino S, Hansen M, Malisan F, Condò I, Bei R, Rea SL, Braeckman BP, Tavernarakis N, Testi R, Ventura N.
Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans.
Exp. Gerontol. 2013 48(2) 191-201 
[ PubMed ID = 23247094 ] [ RRCの論文情報 ]

Fukuyama M, Sakuma K, Park R, Kasuga H, Nagaya R, Atsumi Y, Shimomura Y, Takahashi S, Kajiho H, Rougvie A, Kontani K, Katada T.
C. elegans AMPKs promote survival and arrest germline development during nutrient stress.
Biol Open 2012 1(10) 929-36 
[ PubMed ID = 23213370 ] [ RRCの論文情報 ]

Xie M, Roy R.
Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK compromised C. elegans dauer larvae.
Cell Metab. 2012 16(3) 322-35 
[ PubMed ID = 22921415 ] [ RRCの論文情報 ]

Cunningham KA, Hua Z, Srinivasan S, Liu J, Lee BH, Edwards RH, Ashrafi K.
AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans.
Cell Metab. 2012 16(1) 113-21 
[ PubMed ID = 22768843 ] [ RRCの論文情報 ]

Lemieux GA, Liu J, Mayer N, Bainton RJ, Ashrafi K, Werb Z.
A whole-organism screen identifies new regulators of fat storage.
Nat. Chem. Biol. 2011 7(4) 206-13 
[ PubMed ID = 21390037 ] [ RRCの論文情報 ]

Mair W, Morantte I, Rodrigues AP, Manning G, Montminy M, Shaw RJ, Dillin A.
Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB.
Nature 2011 470(7334) 404-8 
[ PubMed ID = 21331044 ] [ RRCの論文情報 ]

Nukazuka A, Tamaki S, Matsumoto K, Oda Y, Fujisawa H, Takagi S.
A shift of the TOR adaptor from Rictor towards Raptor by semaphorin in C. elegans.
Nat Commun 2011 2 484 
[ PubMed ID = 21952218 ] [ RRCの論文情報 ]

Narbonne P, Hyenne V, Li S, Labbé JC, Roy R.
Differential requirements for STRAD in LKB1-dependent functions in C. elegans.
Development 2010 137(4) 661-70 
[ PubMed ID = 20110331 ] [ RRCの論文情報 ]

Narbonne P, Roy R.
Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival.
Nature 2009 457(7226) 210-4 
[ PubMed ID = 19052547 ] [ RRCの論文情報 ]

Mair W, Panowski SH, Shaw RJ, Dillin A.
Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans.
PLoS ONE 2009 4(2) e4535 
[ PubMed ID = 19229346 ] [ RRCの論文情報 ]

Lee H, Cho JS, Lambacher N, Lee J, Lee SJ, Lee TH, Gartner A, Koo HS.
The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior.
J Biol Chem. 2008 283(22) 14988-93 
[ PubMed ID = 18408008 ] [ RRCの論文情報 ]