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AVAILABLE MUTANTS (ISOLATED)
 変異体 To English >>
 
Record No. 1779
対立遺伝子 tm1779
Sequence Name EEED8.9
CGC Name pink-1
Worm Base 対立遺伝子 tm1779
CGC Name pink-1
Sequence EEED8.9
表現型 homozygous viable. Dr. A. Gartner: no phenotype associating oxidative stress response. Dr. E. Schmidt: J. Biol. Chem. in press.
変異部位 12197/12198-12547/12548 (350 bp deletion)
染色体 II
遺伝子構造 complement(join(10085..10805, 10853..11251, 11299..11528, 11577..11734, 11779..12016, 12068..12199, 12250..12297))
マップポジション -1.78
バランサ
バランサマップポジション
プライマー配列 IntRev:AGCCTCGGGCTTATTAAGGA,IntFwd:TCATTAGGATCTCGCTTGAG,ExtRev:CGCTGAAGGCTCGGATGATG,ExtFwd:GCTAGGTTGGCCATGATAGT
変異体送付先
寄託者 Dr. S. Mitani/NBRP
文献  論文登録
Schiavi A, Maglioni S, Palikaras K, Shaik A, Strappazzon F, Brinkmann V, Torgovnick A, Castelein N, De Henau S, Braeckman BP, Cecconi F, Tavernarakis N, Ventura N.
Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans.
Curr. Biol. 2015 25(14) 1810-22 
[ PubMed ID = 26144971 ] [ RRCの論文情報 ]

Luz AL, Rooney JP, Kubik LL, Gonzalez CP, Song DH, Meyer JN.
Mitochondrial Morphology and Fundamental Parameters of the Mitochondrial Respiratory Chain Are Altered in Caenorhabditis elegans Strains Deficient in Mitochondrial Dynamics and Homeostasis Processes.
PLoS ONE 2015 10(6) e0130940 
[ PubMed ID = 26106885 ] [ RRCの論文情報 ]

Palikaras K, Lionaki E, Tavernarakis N.
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans.
Nature 2015 521(7553) 525-8 
[ PubMed ID = 25896323 ] [ RRCの論文情報 ]

Kirienko NV, Ausubel FM, Ruvkun G.
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa.
Proc. Natl. Acad. Sci. U.S.A. 2015 112(6) 1821-6 
[ PubMed ID = 25624506 ] [ RRCの論文情報 ]

Bornhorst J, Chakraborty S, Meyer S, Lohren H, Brinkhaus SG, Knight AL, Caldwell KA, Caldwell GA, Karst U, Schwerdtle T, Bowman A, Aschner M.
The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans.
Metallomics 2014 6(3) 476-90 
[ PubMed ID = 24452053 ] [ RRCの論文情報 ]

Shen Q, Yamano K, Head BP, Kawajiri S, Cheung JT, Wang C, Cho JH, Hattori N, Youle RJ, van der Bliek AM.
Mutations in Fis1 disrupt orderly disposal of defective mitochondria.
Mol. Biol. Cell 2013 25(1) 145-59 
[ PubMed ID = 24196833 ] [ RRCの論文情報 ]

Bess AS, Leung MC, Ryde IT, Rooney JP, Hinton DE, Meyer JN.
Effects of mutations in mitochondrial dynamics-related genes on the mitochondrial response to ultraviolet C radiation in developing Caenorhabditis elegans.
Worm 2013 2(1) e23763 
[ PubMed ID = 24058863 ] [ RRCの論文情報 ]

Lehmann S, Bass JJ, Szewczyk NJ.
Knockdown of the C. elegans kinome identifies kinases required for normal protein homeostasis, mitochondrial network structure, and sarcomere structure in muscle.
Cell Commun. Signal 2013 11 71 
[ PubMed ID = 24060339 ] [ RRCの論文情報 ]

Bess AS, Crocker TL, Ryde IT, Meyer JN.
Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans.
Nucleic Acids Res. 2012 40(16) 7916-31 
[ PubMed ID = 22718972 ] [ RRCの論文情報 ]

Martinez-Finley EJ, Avila DS, Chakraborty S, Aschner M.
Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases.
Metallomics 2011 3(3) 271-9 
[ PubMed ID = 21210060 ] [ RRCの論文情報 ]

Harrington AJ, Hamamichi S, Caldwell GA, Caldwell KA.
C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease.
Dev. Dyn. 2010 239(5) 1282-95 
[ PubMed ID = 20108318 ] [ RRCの論文情報 ]

Sämann J, Hegermann J, von Gromoff E, Eimer S, Baumeister R, Schmidt E.
Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth.
J Biol Chem. 2009 284(24) 16482-91 
[ PubMed ID = 19251702 ] [ RRCの論文情報 ]