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AVAILABLE MUTANTS (ISOLATED)
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Record No. 1624
対立遺伝子 tm1624
Sequence Name K08H2.6
CGC Name hpl-1
Worm Base 対立遺伝子 tm1624
CGC Name hpl-1
Sequence K08H2.6
表現型 homozygous viable. Dr. M. Han: without obvious phenotype at 20C. Dr. W. Vermeulen: hpl-1 (tm1624) hpl-2 (tm1489) double mutant shows severe UV sensitivity.
変異部位 20665/20666-AA-21161/21162 (496 bp deletion + 2 bp insertion)
染色体 X
遺伝子構造 join(20433..20525, 20601..20684, 20738..20827, 20880..21082, 21756..21840)
マップポジション 10.52
バランサ
バランサマップポジション
プライマー配列 IntFwd:CAAGGGCAATCGCAGATGAG,ExtFwd:GGGGATACGGCTCATTAAGT,IntRev:CTTAGGTTCTTTGGGGCGAG,ExtRev:GCAAGAAATCCCTTGCGACT
変異体送付先
寄託者 Dr. S. Mitani/NBRP
文献  論文登録
Mao H, Zhu C, Zong D, Weng C, Yang X, Huang H, Liu D, Feng X, Guang S.
The Nrde Pathway Mediates Small-RNA-Directed Histone H3 Lysine 27 Trimethylation in Caenorhabditis elegans.
Curr. Biol. 2015 25(18) 2398-403 
[ PubMed ID = 26365259 ] [ RRCの論文情報 ]

Zhuang JJ, Banse SA, Hunter CP.
The nuclear argonaute NRDE-3 contributes to transitive RNAi in Caenorhabditis elegans.
Genetics 2013 194(1) 117-31 
[ PubMed ID = 23457236 ] [ RRCの論文情報 ]

Zheng C, Karimzadegan S, Chiang V, Chalfie M.
Histone methylation restrains the expression of subtype-specific genes during terminal neuronal differentiation in Caenorhabditis elegans.
PLoS Genet. 2013 9(12) e1004017 
[ PubMed ID = 24348272 ] [ RRCの論文情報 ]

Studencka M, Wesołowski R, Opitz L, Salinas-Riester G, Wisniewski JR, Jedrusik-Bode M.
Transcriptional repression of Hox genes by C. elegans HP1/HPL and H1/HIS-24.
PLoS Genet. 2012 8(9) e1002940 
[ PubMed ID = 23028351 ] [ RRCの論文情報 ]

Shirayama M, Seth M, Lee HC, Gu W, Ishidate T, Conte D Jr, Mello CC.
piRNAs initiate an epigenetic memory of nonself RNA in the C. elegans germline.
Cell 2012 150(1) 65-77 
[ PubMed ID = 22738726 ] [ RRCの論文情報 ]

Studencka M, Konzer A, Moneron G, Wenzel D, Opitz L, Salinas-Riester G, Bedet C, Krüger M, Hell SW, Wisniewski JR, Schmidt H, Palladino F, Schulze E, Jedrusik-Bode M.
Novel roles of Caenorhabditis elegans heterochromatin protein HP1 and linker histone in the regulation of innate immune gene expression.
Mol. Cell. Biol. 2012 32(2) 251-65 
[ PubMed ID = 22083954 ] [ RRCの論文情報 ]

Yuen KW, Nabeshima K, Oegema K, Desai A.
Rapid de novo centromere formation occurs independently of heterochromatin protein 1 in C. elegans embryos.
Curr. Biol. 2011 21(21) 1800-7 
[ PubMed ID = 22018540 ] [ RRCの論文情報 ]

Koester-Eiserfunke N, Fischle W.
H3K9me2/3 binding of the MBT domain protein LIN-61 is essential for Caenorhabditis elegans vulva development.
PLoS Genet. 2011 7(3) e1002017 
[ PubMed ID = 21437264 ] [ RRCの論文情報 ]

Meister P, Schott S, Bedet C, Xiao Y, Rohner S, Bodennec S, Hudry B, Molin L, Solari F, Gasser SM, Palladino F.
Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism.
Genome Biol. 2011 12(12) R123 
[ PubMed ID = 22185090 ] [ RRCの論文情報 ]

Black JC, Allen A, Van Rechem C, Forbes E, Longworth M, Tschöp K, Rinehart C, Quiton J, Walsh R, Smallwood A, Dyson NJ, Whetstine JR.
Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression.
Mol. Cell 2010 40(5) 736-48 
[ PubMed ID = 21145482 ] [ RRCの論文情報 ]

Hall SE, Beverly M, Russ C, Nusbaum C, Sengupta P.
A cellular memory of developmental history generates phenotypic diversity in C. elegans.
Curr. Biol. 2010 20(2) 149-55 
[ PubMed ID = 20079644 ] [ RRCの論文情報 ]

Luijsterburg MS, Dinant C, Lans H, Stap J, Wiernasz E, Lagerwerf S, Warmerdam DO, Lindh M, Brink MC, Dobrucki JW, Aten JA, Fousteri MI, Jansen G, Dantuma NP, Vermeulen W, Mullenders LH, Houtsmuller AB, Verschure PJ, van Driel R.
Heterochromatin protein 1 is recruited to various types of DNA damage.
J Cell Biol. 2009 185(4) 577-86 
[ PubMed ID = 19451271 ] [ RRCの論文情報 ]

Simonet T, Dulermo R, Schott S, Palladino F.
Antagonistic functions of SET-2/SET1 and HPL/HP1 proteins in C. elegans development.
Dev. Biol. 2007 312(1) 367-83 
[ PubMed ID = 17967446 ] [ RRCの論文情報 ]

Grote P, Conradt B.
The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C. elegans.
Dev. Cell 2006 11(4) 561-73 
[ PubMed ID = 17011494 ] [ RRCの論文情報 ]

Schott S, Coustham V, Simonet T, Bedet C, Palladino F.
Unique and redundant functions of C. elegans HP1 proteins in post-embryonic development.
Dev. Biol. 2006 298(1) 176-87 
[ PubMed ID = 16905130 ] [ RRCの論文情報 ]