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AVAILABLE MUTANTS (ISOLATED)
 変異体 To English >>
 
Record No. 1552
対立遺伝子 tm1552
Sequence Name F16F9.5
CGC Name mec-10
Worm Base 対立遺伝子 tm1552
CGC Name mec-10
Sequence F16F9.5
表現型 homozygous viable. Dr. M. Driscoll: touch insensitive.
変異部位 30081/30082-30529/30530 (448 bp deletion)
染色体 X
遺伝子構造 complement(join(27406..27579, 27668..27743, 27791..27919, 28137..28312, 28470..28565, 28627..28787, 29053..29153, 29197..29271, 29322..29404, 29454..29546, 29822..29898, 30056..30125, 30229..30525, 30576..30658, 30864..30985, 31232..31324, 31372..31640))
マップポジション 0.01
バランサ
バランサマップポジション
プライマー配列 ExtRev:TGCTTGGGCAAGCTCCAAAC,IntRev:TGGGAGGGAGCTTCATCTTA,ExtFwd:GGTCCAGCTCTCACACTGGA,IntFwd:GTAGGGTCTGCAACTAGCTC
変異体送付先
寄託者 Dr. S. Mitani/NBRP
文献  論文登録
Russell J, Vidal-Gadea AG, Makay A, Lanam C, Pierce-Shimomura JT.
Humidity sensation requires both mechanosensory and thermosensory pathways in Caenorhabditis elegans.
Proc. Natl. Acad. Sci. U.S.A. 2014 111(22) 8269-74 
[ PubMed ID = 24843133 ] [ RRCの論文情報 ]

Yemini E, Jucikas T, Grundy LJ, Brown AE, Schafer WR.
A database of Caenorhabditis elegans behavioral phenotypes.
Nat. Methods 2013 10(9) 877-9 
[ PubMed ID = 23852451 ] [ RRCの論文情報 ]

Rabinowitch I, Chatzigeorgiou M, Schafer WR.
A gap junction circuit enhances processing of coincident mechanosensory inputs.
Curr. Biol. 2013 23(11) 963-7 
[ PubMed ID = 23707432 ] [ RRCの論文情報 ]

Mohammadi A, Byrne Rodgers J, Kotera I, Ryu WS.
Behavioral response of Caenorhabditis elegans to localized thermal stimuli.
BMC Neurosci 2013 14 66 
[ PubMed ID = 23822173 ] [ RRCの論文情報 ]

Sanders J, Nagy S, Fetterman G, Wright C, Treinin M, Biron D.
The Caenorhabditis elegans interneuron ALA is (also) a high-threshold mechanosensor.
BMC Neurosci 2013 14 156 
[ PubMed ID = 24341457 ] [ RRCの論文情報 ]

Cohen E, Yemini E, Schafer W, Feitelson DG, Treinin M.
Locomotion analysis identifies roles of mechanosensory neurons in governing locomotion dynamics of C. elegans.
J. Exp. Biol. 2012 215(Pt 20) 3639-48 
[ PubMed ID = 22811252 ] [ RRCの論文情報 ]

Husson SJ, Costa WS, Wabnig S, Stirman JN, Watson JD, Spencer WC, Akerboom J, Looger LL, Treinin M, Miller DM 3rd, Lu H, Gottschalk A.
Optogenetic analysis of a nociceptor neuron and network reveals ion channels acting downstream of primary sensors.
Curr. Biol. 2012 22(9) 743-52 
[ PubMed ID = 22483941 ] [ RRCの論文情報 ]

Arnadóttir J, O'Hagan R, Chen Y, Goodman MB, Chalfie M.
The DEG/ENaC protein MEC-10 regulates the transduction channel complex in Caenorhabditis elegans touch receptor neurons.
J. Neurosci. 2011 31(35) 12695-704 
[ PubMed ID = 21880930 ] [ RRCの論文情報 ]

Chatzigeorgiou M, Schafer WR.
Lateral facilitation between primary mechanosensory neurons controls nose touch perception in C. elegans.
Neuron 2011 70(2) 299-309 
[ PubMed ID = 21521615 ] [ RRCの論文情報 ]

Albeg A, Smith CJ, Chatzigeorgiou M, Feitelson DG, Hall DH, Schafer WR, Miller DM 3rd, Treinin M.
C. elegans multi-dendritic sensory neurons: morphology and function.
Mol. Cell. Neurosci. 2011 46(1) 308-17 
[ PubMed ID = 20971193 ] [ RRCの論文情報 ]

Li W, Kang L, Piggott BJ, Feng Z, Xu XZ.
The neural circuits and sensory channels mediating harsh touch sensation in Caenorhabditis elegans.
Nat Commun 2011 2 315 
[ PubMed ID = 21587232 ] [ RRCの論文情報 ]

Chatzigeorgiou M, Grundy L, Kindt KS, Lee WH, Driscoll M, Schafer WR.
Spatial asymmetry in the mechanosensory phenotypes of the C. elegans DEG/ENaC gene mec-10.
J. Neurophysiol. 2010 104(6) 3334-44 
[ PubMed ID = 20881202 ] [ RRCの論文情報 ]

Chatzigeorgiou M, Yoo S, Watson JD, Lee WH, Spencer WC, Kindt KS, Hwang SW, Miller DM 3rd, Treinin M, Driscoll M, Schafer WR.
Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors.
Nat. Neurosci. 2010 13(7) 861-8 
[ PubMed ID = 20512132 ] [ RRCの論文情報 ]

Zhang W, Bianchi L, Lee WH, Wang Y, Israel S, Driscoll M.
Intersubunit interactions between mutant DEG/ENaCs induce synthetic neurotoxicity.
Cell Death Differ. 2008 15(11) 1794-803 
[ PubMed ID = 18670436 ] [ RRCの論文情報 ]