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AVAILABLE MUTANTS (ISOLATED)
 変異体 To English >>
 
Record No. 1523
対立遺伝子 tm1523
Sequence Name T20D3.7
CGC Name vps-26
Worm Base 対立遺伝子 tm1523
CGC Name vps-26
Sequence T20D3.7
表現型 lethal or sterile. Dr. H.C. Korswagen: QL and QR daughter cells, HSN migration defects, polarity of V5 division defects, similar to egl-20. Dr. G. Hermann: wild-type gut granules. Dr. K. Shen: normal synapse formation as determined by RAB-3 and CCB-1 localization to presynaptic sites in HSNL. Dr. S. Shaham: no obvious defects in glia development.
変異部位 14539/14540-14941/14942 (402 bp deletion)
染色体 IV
遺伝子構造 complement(join(13168..13371, 13654..14137, 14214..14370, 14721..14874, 14930..15157))
マップポジション 4.19
バランサ nT1 [qIs51]
バランサマップポジション
プライマー配列 ExtFwd:TACCTAACGAGACCCAAGTC,IntFwd:CTCTGGGGCGGAACGTGTTT,IntRev:CTGGCCTCAGCTCTGCTATT,ExtRev:ACATCCGTCAGCACTGGCCT
変異体送付先
寄託者 Dr. S. Mitani/NBRP
文献  論文登録
Beer KB, Rivas-Castillo J, Kuhn K, Fazeli G, Karmann B, Nance JF, Stigloher C, Wehman AM.
Extracellular vesicle budding is inhibited by redundant regulators of TAT-5 flippase localization and phospholipid asymmetry.
Proc. Natl. Acad. Sci. U.S.A. 2018 115(6) E1127-E1136 
[ PubMed ID = 29367422 ] [ RRCの論文情報 ]

Bai Z, Grant BD.
A TOCA/CDC-42/PAR/WAVE functional module required for retrograde endocytic recycling.
Proc. Natl. Acad. Sci. U.S.A. 2015 112(12) E1443-52 
[ PubMed ID = 25775511 ] [ RRCの論文情報 ]

Oikonomou G, Perens EA, Lu Y, Shaham S.
Some, but not all, retromer components promote morphogenesis of C. elegans sensory compartments.
Dev. Biol. 2011 362(1) 42-9 
[ PubMed ID = 22138055 ] [ RRCの論文情報 ]

Harterink M, Port F, Lorenowicz MJ, McGough IJ, Silhankova M, Betist MC, van Weering JRT, van Heesbeen RGHP, Middelkoop TC, Basler K, Cullen PJ, Korswagen HC.
A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion.
Nat. Cell Biol. 2011 13(8) 914-923 
[ PubMed ID = 21725319 ] [ RRCの論文情報 ]

Lu N, Shen Q, Mahoney TR, Liu X, Zhou Z.
Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling.
Mol. Biol. Cell 2010 22(3) 354-74 
[ PubMed ID = 21148288 ] [ RRCの論文情報 ]

Lu N, Shen Q, Mahoney TR, Liu X, Zhou Z.
Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling.
Mol. Biol. Cell 2010 22(3) 354-74 
[ PubMed ID = 21148288 ] [ RRCの論文情報 ]

Silhankova M, Port F, Harterink M, Basler K, Korswagen HC.
Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells.
EMBO J. 2010 29(24) 4094-105 
[ PubMed ID = 21076391 ] [ RRCの論文情報 ]

Chen D, Xiao H, Zhang K, Wang B, Gao Z, Jian Y, Qi X, Sun J, Miao L, Yang C.
Retromer is required for apoptotic cell clearance by phagocytic receptor recycling.
Science 2010 327(5970) 1261-4 
[ PubMed ID = 20133524 ] [ RRCの論文情報 ]

Coudreuse DY, Roël G, Betist MC, Destrée O, Korswagen HC.
Wnt gradient formation requires retromer function in Wnt-producing cells.
Science 2006 312(5775) 921-4 
[ PubMed ID = 16645052 ] [ RRCの論文情報 ]

Prasad BC, Clark SG.
Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans.
Development 2006 133(9) 1757-66 
[ PubMed ID = 16571624 ] [ RRCの論文情報 ]