HOME MUTANTS PROMOTER SEARCH FAQ & CONTACT  
ミニアンケート集計結果はこちら     MUTANTS
キーワード検索
分離済み変異体
スクリーニング中変異体
  

分離済み変異体
変異体一覧
項目検索
分譲申し込み方法
MTA
技術的なコメント
論文情報登録

スクリーニング中変異体
進行状況
スクリーニング申し込み方法
スクリーニング申し込み

フィードバック
フィードバックの
お願い
 
 
 

Last Update
null

 
staff only
AVAILABLE MUTANTS (ISOLATED)
 変異体 To English >>
 
Record No. 1489
対立遺伝子 tm1489
Sequence Name K01G5.2a
CGC Name hpl-2
Worm Base 対立遺伝子 tm1489
CGC Name hpl-2
Sequence K01G5.2a
表現型 homozygous viable. Dr. R.H. Horvitz: not completely penetrant multivulva and sterile at 25 degree, synthetic multivulva with mutations in class A, B and C genes. Dr. M. Han: WT at 20 degree, partial Muv at 25 degree. tm1489; lin-8 (null) is partial Muv at 20C, complete and obvious Muv at 25C. tm1489; lin-15A (RNAi) is Muv at 20C. Dr. W. Vermeulen: hpl-1 (tm1624) hpl-2 (tm1489) double mutant shows severe UV sensitivity.
変異部位 14347/14348-15019/15020 (672 bp deletion)
染色体 III
遺伝子構造 complement(join(13194..13266, 13966..14204, 14472..14645, 14920..14961))
マップポジション 5.24
バランサ
バランサマップポジション
プライマー配列 ExtFwd:GGCACTTATGTGCAGTACAG,IntRev:TCAGAGCTCCTAACCTACCT,IntFwd:GTGCAGTACAGCCGGCATAT,ExtRev:TACATGCAACAAACCGCGCT
変異体送付先
寄託者 Dr. S. Mitani/NBRP
文献  論文登録
Vandamme J, Sidoli S, Mariani L, Friis C, Christensen J, Helin K, Jensen ON, Salcini AE.
H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans.
Nucleic Acids Res. 2015 43(20) 9694-710 
[ PubMed ID = 26476455 ] [ RRCの論文情報 ]

Mao H, Zhu C, Zong D, Weng C, Yang X, Huang H, Liu D, Feng X, Guang S.
The Nrde Pathway Mediates Small-RNA-Directed Histone H3 Lysine 27 Trimethylation in Caenorhabditis elegans.
Curr. Biol. 2015 25(18) 2398-403 
[ PubMed ID = 26365259 ] [ RRCの論文情報 ]

Garrigues JM, Sidoli S, Garcia BA, Strome S.
Defining heterochromatin in C. elegans through genome-wide analysis of the heterochromatin protein 1 homolog HPL-2.
Genome Res. 2015 25(1) 76-88 
[ PubMed ID = 25467431 ] [ RRCの論文情報 ]

Juang BT, Ludwig AL, Benedetti KL, Gu C, Collins K, Morales C, Asundi A, Wittmann T, L'Etoile N, Hagerman PJ.
Expression of an expanded CGG-repeat RNA in a single pair of primary sensory neurons impairs olfactory adaptation in Caenorhabditis elegans.
Hum. Mol. Genet. 2014 23(18) 4945-59 
[ PubMed ID = 24821701 ] [ RRCの論文情報 ]

Kozlowski L, Garvis S, Bedet C, Palladino F.
The Caenorhabditis elegans HP1 family protein HPL-2 maintains ER homeostasis through the UPR and hormesis.
Proc. Natl. Acad. Sci. U.S.A. 2014 111(16) 5956-61 
[ PubMed ID = 24715729 ] [ RRCの論文情報 ]

Zheng C, Karimzadegan S, Chiang V, Chalfie M.
Histone methylation restrains the expression of subtype-specific genes during terminal neuronal differentiation in Caenorhabditis elegans.
PLoS Genet. 2013 9(12) e1004017 
[ PubMed ID = 24348272 ] [ RRCの論文情報 ]

Studencka M, Wesołowski R, Opitz L, Salinas-Riester G, Wisniewski JR, Jedrusik-Bode M.
Transcriptional repression of Hox genes by C. elegans HP1/HPL and H1/HIS-24.
PLoS Genet. 2012 8(9) e1002940 
[ PubMed ID = 23028351 ] [ RRCの論文情報 ]

McNally KL, Fabritius AS, Ellefson ML, Flynn JR, Milan JA, McNally FJ.
Kinesin-1 prevents capture of the oocyte meiotic spindle by the sperm aster.
Dev. Cell 2012 22(4) 788-98 
[ PubMed ID = 22465668 ] [ RRCの論文情報 ]

Studencka M, Konzer A, Moneron G, Wenzel D, Opitz L, Salinas-Riester G, Bedet C, Krüger M, Hell SW, Wisniewski JR, Schmidt H, Palladino F, Schulze E, Jedrusik-Bode M.
Novel roles of Caenorhabditis elegans heterochromatin protein HP1 and linker histone in the regulation of innate immune gene expression.
Mol. Cell. Biol. 2012 32(2) 251-65 
[ PubMed ID = 22083954 ] [ RRCの論文情報 ]

Yuen KW, Nabeshima K, Oegema K, Desai A.
Rapid de novo centromere formation occurs independently of heterochromatin protein 1 in C. elegans embryos.
Curr. Biol. 2011 21(21) 1800-7 
[ PubMed ID = 22018540 ] [ RRCの論文情報 ]

Updike DL, Hachey SJ, Kreher J, Strome S.
P granules extend the nuclear pore complex environment in the C. elegans germ line.
J. Cell Biol. 2011 192(6) 939-48 
[ PubMed ID = 21402789 ] [ RRCの論文情報 ]

Koester-Eiserfunke N, Fischle W.
H3K9me2/3 binding of the MBT domain protein LIN-61 is essential for Caenorhabditis elegans vulva development.
PLoS Genet. 2011 7(3) e1002017 
[ PubMed ID = 21437264 ] [ RRCの論文情報 ]

Petrella LN, Wang W, Spike CA, Rechtsteiner A, Reinke V, Strome S.
synMuv B proteins antagonize germline fate in the intestine and ensure C. elegans survival.
Development 2011 138(6) 1069-79 
[ PubMed ID = 21343362 ] [ RRCの論文情報 ]

Meister P, Schott S, Bedet C, Xiao Y, Rohner S, Bodennec S, Hudry B, Molin L, Solari F, Gasser SM, Palladino F.
Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism.
Genome Biol. 2011 12(12) R123 
[ PubMed ID = 22185090 ] [ RRCの論文情報 ]

Black JC, Allen A, Van Rechem C, Forbes E, Longworth M, Tschöp K, Rinehart C, Quiton J, Walsh R, Smallwood A, Dyson NJ, Whetstine JR.
Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression.
Mol. Cell 2010 40(5) 736-48 
[ PubMed ID = 21145482 ] [ RRCの論文情報 ]

Wagner CR, Kuervers L, Baillie DL, Yanowitz JL.
xnd-1 regulates the global recombination landscape in Caenorhabditis elegans.
Nature 2010 467(7317) 839-43 
[ PubMed ID = 20944745 ] [ RRCの論文情報 ]

Hall SE, Beverly M, Russ C, Nusbaum C, Sengupta P.
A cellular memory of developmental history generates phenotypic diversity in C. elegans.
Curr. Biol. 2010 20(2) 149-55 
[ PubMed ID = 20079644 ] [ RRCの論文情報 ]

Luijsterburg MS, Dinant C, Lans H, Stap J, Wiernasz E, Lagerwerf S, Warmerdam DO, Lindh M, Brink MC, Dobrucki JW, Aten JA, Fousteri MI, Jansen G, Dantuma NP, Vermeulen W, Mullenders LH, Houtsmuller AB, Verschure PJ, van Driel R.
Heterochromatin protein 1 is recruited to various types of DNA damage.
J. Cell Biol. 2009 185(4) 577-86 
[ PubMed ID = 19451271 ] [ RRCの論文情報 ]

Schott S, Ramos F, Coustham V, Palladino F.
HPL-2/HP1 prevents inappropriate vulval induction in Caenorhabditis elegans by acting in both HYP7 and vulval precursor cells.
Genetics 2009 181(2) 797-801 
[ PubMed ID = 19064713 ] [ RRCの論文情報 ]

Kirienko NV, McEnerney JD, Fay DS.
Coordinated regulation of intestinal functions in C. elegans by LIN-35/Rb and SLR-2.
PLoS Genet. 2008 4(4) e1000059 
[ PubMed ID = 18437219 ] [ RRCの論文情報 ]

Simonet T, Dulermo R, Schott S, Palladino F.
Antagonistic functions of SET-2/SET1 and HPL/HP1 proteins in C. elegans development.
Dev. Biol. 2007 312(1) 367-83 
[ PubMed ID = 17967446 ] [ RRCの論文情報 ]

Andersen EC, Horvitz HR.
Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development.
Development 2007 134(16) 2991-9 
[ PubMed ID = 17634190 ] [ RRCの論文情報 ]

Grote P, Conradt B.
The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C. elegans.
Dev. Cell 2006 11(4) 561-73 
[ PubMed ID = 17011494 ] [ RRCの論文情報 ]

Schott S, Coustham V, Simonet T, Bedet C, Palladino F.
Unique and redundant functions of C. elegans HP1 proteins in post-embryonic development.
Dev. Biol. 2006 298(1) 176-87 
[ PubMed ID = 16905130 ] [ RRCの論文情報 ]

Coustham V, Bedet C, Monier K, Schott S, Karali M, Palladino F.
The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development.
Dev. Biol. 2006 297(2) 308-22 
[ PubMed ID = 16890929 ] [ RRCの論文情報 ]

Andersen EC, Lu X, Horvitz HR.
C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates.
Development 2006 133(14) 2695-704 
[ PubMed ID = 16774993 ] [ RRCの論文情報 ]