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AVAILABLE MUTANTS (ISOLATED)
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Record No. 1447
対立遺伝子 tm1447
Sequence Name Y116A8C.12
CGC Name arf-6
Worm Base 対立遺伝子 tm1447
CGC Name arf-6
Sequence Y116A8C.12
表現型 homozygous viable. Dr. M. Han: WT vulval development, slow growth and WT touch response. Dr. K. Shen: Normal HSN vulval presynaptic vesicle clusters (unc-86::SNB-1::YFP), no obvious egg laying defects. Dr. Y. Jin: no specific neuronal phenotype is found. Dr. C. Rongo: normal GLR-1::GFP localization and expression. Dr. J-L. Bessereau: no specific neuronal phenotype. Dr. G. Garriga: extra AVM/PVM in arf-1: arf-6 double mutants. Dr. O. Blacque: dye-filling normal. Dr. J. Lee: normal touch response.
変異部位 46750/46751-49013/49014 (2263 bp deletion)
染色体 IV
遺伝子構造 join(47037..47118, 47186..47289, 47380..47477, 47561..47661, 47882..47942, 49289..49370)
マップポジション 15.8
バランサ
バランサマップポジション
プライマー配列 ExtRev:GTCTCCGGTTGAAGCACATG,IntRev:GGTTGGACGTACCTGCAAAG,ExtFwd:CTAGGAGATTACAGGCCCAT,IntFwd:CGCAAAAACGAATGCGTAGC
変異体送付先
寄託者 Dr. S. Mitani/NBRP
文献  論文登録
Zhai J, Zhang L, Mojsilovic-Petrovic J, Jian X, Thomas J, Homma K, Schmitz A, Famulok M, Ichijo H, Argon Y, Randazzo PA, Kalb RG.
Inhibition of Cytohesins Protects against Genetic Models of Motor Neuron Disease.
J. Neurosci. 2015 35(24) 9088-105 
[ PubMed ID = 26085633 ] [ RRCの論文情報 ]

Skorobogata O, Escobar-Restrepo JM, Rocheleau CE.
An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 EGFR basolateral localization and signaling during C. elegans vulva induction.
PLoS Genet. 2014 10(10) e1004728 
[ PubMed ID = 25329472 ] [ RRCの論文情報 ]

Teuliere J, Cordes S, Singhvi A, Talavera K, Garriga G.
Asymmetric neuroblast divisions producing apoptotic cells require the cytohesin GRP-1 in Caenorhabditis elegans.
Genetics 2014 198(1) 229-47 
[ PubMed ID = 25053664 ] [ RRCの論文情報 ]

Gleason RJ, Akintobi AM, Grant BD, Padgett RW.
BMP signaling requires retromer-dependent recycling of the type I receptor.
Proc. Natl. Acad. Sci. U.S.A. 2014 111(7) 2578-83 
[ PubMed ID = 24550286 ] [ RRCの論文情報 ]

Shi A, Liu O, Koenig S, Banerjee R, Chen CC, Eimer S, Grant BD.
RAB-10-GTPase-mediated regulation of endosomal phosphatidylinositol-4,5-bisphosphate.
Proc. Natl. Acad. Sci. U.S.A. 2012 109(35) E2306-15 
[ PubMed ID = 22869721 ] [ RRCの論文情報 ]

Kimata T, Tanizawa Y, Can Y, Ikeda S, Kuhara A, Mori I.
Synaptic polarity depends on phosphatidylinositol signaling regulated by myo-inositol monophosphatase in Caenorhabditis elegans.
Genetics 2012 191(2) 509-21 
[ PubMed ID = 22446320 ] [ RRCの論文情報 ]

Singhvi A, Teuliere J, Talavera K, Cordes S, Ou G, Vale RD, Prasad BC, Clark SG, Garriga G.
The Arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric neuroblast divisions.
Curr. Biol. 2011 21(11) 948-54 
[ PubMed ID = 21596567 ] [ RRCの論文情報 ]