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AVAILABLE MUTANTS (ISOLATED)
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Record No. 1422
対立遺伝子 tm1422
Sequence Name B0410.2
CGC Name vang-1
Worm Base 対立遺伝子 tm1422
CGC Name vang-1
Sequence B0410.2
表現型 homozygous viable. Dr. A. Colavita: ectopic VC axons. Dr. G. Garriga: no obvious HSN or Q neuroblast migration defects. Dr. H. Sawa: no Psa phenotype. Dr. C. Yang: normal cell death phenotype.
変異部位 1420/1421-2016/2017 (596 bp deletion)
染色体 X
遺伝子構造 join(416..571, 1384..1517, 1568..1700, 1753..1971, 2739..3181, 3526..3744, 3796..3964, 4720..4845)
マップポジション -12.68
バランサ
バランサマップポジション
プライマー配列 ExtFwd:GCTCTGGGTACCAATATGTG,IntFwd:GCCAGTAGGTAACCAATTCA,ExtRev:GCCAGCGCCAATGTTCAATG,IntRev:GTCTGGATCGCGAACAATAG
変異体送付先
寄託者 Dr. S. Mitani/NBRP
文献  論文登録
Chien J, Devkota R, Yosef N, Mörck C.
Regulation of Axon Guidance by the Wnt Receptor Ror/CAM-1 in the PVT Guidepost Cell in Caenorhabditis elegans.
Genetics 2017 207(4) 1533-1545 
[ PubMed ID = 28993416 ] [ RRCの論文情報 ]

Shah PK, Tanner MR, Kovacevic I, Rankin A, Marshall TE, Noblett N, Tran NN, Roenspies T, Hung J, Chen Z, Slatculescu C, Perkins TJ, Bao Z, Colavita A.
PCP and SAX-3/Robo Pathways Cooperate to Regulate Convergent Extension-Based Nerve Cord Assembly in C. elegans.
Dev. Cell 2017 41(2) 195-203.e3 
[ PubMed ID = 28441532 ] [ RRCの論文情報 ]

Chen CH, He CW, Liao CP, Pan CL.
A Wnt-planar polarity pathway instructs neurite branching by restricting F-actin assembly through endosomal signaling.
PLoS Genet. 2017 13(4) e1006720 
[ PubMed ID = 28384160 ] [ RRCの論文情報 ]

Carr D, Sanchez-Alvarez L, Imai JH, Slatculescu C, Noblett N, Mao L, Beese L, Colavita A.
A Farnesyltransferase Acts to Inhibit Ectopic Neurite Formation in C. elegans.
PLoS ONE 2016 11(6) e0157537 
[ PubMed ID = 27300162 ] [ RRCの論文情報 ]

Chien SC, Gurling M, Kim C, Craft T, Forrester W, Garriga G.
Autonomous and nonautonomous regulation of Wnt-mediated neuronal polarity by the C. elegans Ror kinase CAM-1.
Dev. Biol. 2015 404(1) 55-65 
[ PubMed ID = 25917219 ] [ RRCの論文情報 ]

Mentink RA, Middelkoop TC, Rella L, Ji N, Tang CY, Betist MC, van Oudenaarden A, Korswagen HC.
Cell intrinsic modulation of Wnt signaling controls neuroblast migration in C. elegans.
Dev. Cell 2014 31(2) 188-201 
[ PubMed ID = 25373777 ] [ RRCの論文情報 ]

Kulkarni G, Xu Z, Mohamed AM, Li H, Tang X, Limerick G, Wadsworth WG.
Experimental evidence for UNC-6 (netrin) axon guidance by stochastic fluctuations of intracellular UNC-40 (DCC) outgrowth activity.
Biol Open 2013 2(12) 1300-12 
[ PubMed ID = 24337114 ] [ RRCの論文情報 ]

Honnen SJ, Büchter C, Schröder V, Hoffmann M, Kohara Y, Kampkötter A, Bossinger O.
C. elegans VANG-1 modulates life span via insulin/IGF-1-like signaling.
PLoS ONE 2012 7(2) e32183 
[ PubMed ID = 22359667 ] [ RRCの論文情報 ]

Yamamoto Y, Takeshita H, Sawa H.
Multiple Wnts redundantly control polarity orientation in Caenorhabditis elegans epithelial stem cells.
PLoS Genet. 2011 7(10) e1002308 
[ PubMed ID = 22022276 ] [ RRCの論文情報 ]

Sanchez-Alvarez L, Visanuvimol J, McEwan A, Su A, Imai JH, Colavita A.
VANG-1 and PRKL-1 cooperate to negatively regulate neurite formation in Caenorhabditis elegans.
PLoS Genet. 2011 7(9) e1002257 
[ PubMed ID = 21912529 ] [ RRCの論文情報 ]

Steimel A, Wong L, Najarro EH, Ackley BD, Garriga G, Hutter H.
The Flamingo ortholog FMI-1 controls pioneer-dependent navigation of follower axons in C. elegans.
Development 2010 137(21) 3663-73 
[ PubMed ID = 20876647 ] [ RRCの論文情報 ]

Hoffmann M, Segbert C, Helbig G, Bossinger O.
Intestinal tube formation in Caenorhabditis elegans requires vang-1 and egl-15 signaling.
Dev. Biol. 2009 339(2) 268-79 
[ PubMed ID = 20004187 ] [ RRCの論文情報 ]