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AVAILABLE MUTANTS (ISOLATED)
 変異体 To English >>
 
Record No. 1380
対立遺伝子 tm1380
Sequence Name T05H10.5
CGC Name ufd-2
Worm Base 対立遺伝子 tm1380
CGC Name ufd-2
Sequence T05H10.5
表現型 homozygous viable. Dr. T. Ogura: Genes to Cells: 12, 1063 (2007). Dr. R. Baumeister: Dev. Biol. 312, 193 (2007). Dr. T. Hoppe: Nat. Cell Biol. 9, 379 (2007).
変異部位 21052/21053-21967/21968 (915 bp deletion)
染色体 II
遺伝子構造 join(20407..20463, 20518..20832, 20878..21799, 21850..22759, 22808..23162, 23215..23598)
マップポジション 0.66
バランサ
バランサマップポジション
プライマー配列 ExtRev:CTGTGTTGTCCCATTCGACT,IntFwd:GTGATGCTTCTGTGGTGCGT,ExtFwd:AGGCTTGCAGCCGATGGACA,IntRev:GAATGAACTCTGCTCCGCAT
変異体送付先
寄託者 Dr. S. Mitani/NBRP
文献  論文登録
Jablonski AM, Lamitina T, Liachko NF, Sabatella M, Lu J, Zhang L, Ostrow LW, Gupta P, Wu CY, Doshi S, Mojsilovic-Petrovic J, Lans H, Wang J, Kraemer B, Kalb RG.
Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance.
J Neurosci. 2015 35(42) 14286-306 
[ PubMed ID = 26490867 ] [ RRCの論文情報 ]

Periz G, Lu J, Zhang T, Kankel MW, Jablonski AM, Kalb R, McCampbell A, Wang J.
Regulation of protein quality control by UBE4B and LSD1 through p53-mediated transcription.
PLoS Biol. 2015 13(4) e1002114 
[ PubMed ID = 25837623 ] [ RRCの論文情報 ]

Murayama Y, Ogura T, Yamanaka K.
Characterization of C-terminal adaptors, UFD-2 and UFD-3, of CDC-48 on the polyglutamine aggregation in C. elegans.
Biochem. Biophys. Res. Commun. 2015 459(1) 154-60 
[ PubMed ID = 25721663 ] [ RRCの論文情報 ]

Crook-McMahon HM, Oláhová M, Button EL, Winter JJ, Veal EA.
Genome-wide screening identifies new genes required for stress-induced phase 2 detoxification gene expression in animals.
BMC Biol. 2014 12 64 
[ PubMed ID = 25204677 ] [ RRCの論文情報 ]

Liu G, Rogers J, Murphy CT, Rongo C.
EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan.
EMBO J. 2011 30(15) 2990-3003 
[ PubMed ID = 21673654 ] [ RRCの論文情報 ]

Segref A, Torres S, Hoppe T.
A screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans.
Genetics 2011 187(4) 1235-40 
[ PubMed ID = 21288877 ] [ RRCの論文情報 ]

Kuhlbrodt K, Janiesch PC, Kevei É, Segref A, Barikbin R, Hoppe T.
The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis.
Nat. Cell Biol. 2011 13(3) 273-81 
[ PubMed ID = 21317884 ] [ RRCの論文情報 ]

Nyamsuren O, Faggionato D, Loch W, Schulze E, Baumeister R.
A mutation in CHN-1/CHIP suppresses muscle degeneration in Caenorhabditis elegans.
Dev. Biol. 2007 312(1) 193-202 
[ PubMed ID = 17961535 ] [ RRCの論文情報 ]

Sasagawa Y, Yamanaka K, Ogura T.
ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in Caenorhabditis elegans.
Genes Cells 2007 12(9) 1063-73 
[ PubMed ID = 17825049 ] [ RRCの論文情報 ]

O'Rourke SM, Dorfman MD, Carter JC, Bowerman B.
Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants.
PLoS Genet. 2007 3(8) e128 
[ PubMed ID = 17676955 ] [ RRCの論文情報 ]

Janiesch PC, Kim J, Mouysset J, Barikbin R, Lochmüller H, Cassata G, Krause S, Hoppe T.
The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy.
Nat. Cell Biol. 2007 9(4) 379-90 
[ PubMed ID = 17369820 ] [ RRCの論文情報 ]