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AVAILABLE MUTANTS (ISOLATED)
 変異体 To English >>
 
Record No. 1325
対立遺伝子 tm1325
Sequence Name C09B7.1
CGC Name ser-7
Worm Base 対立遺伝子 tm1325
CGC Name ser-7
Sequence C09B7.1
表現型 homozygous viable. Dr. R. Komuniecki: Genetics in press, Dr. K. Ashrafi: Cell Metab 7, 533 (2008).
変異部位 42634/42635-GGGAANNAAAACCCTCCCTNNANNANNATNNGGANNCC-43376/43377 (742 bp deletion + 38 bp insertion)
染色体 X
遺伝子構造 join(36058..36389, 37087..37342, 40604..40933, 42388..42560, 43169..43306, 44163..44201, 44465..44504)
マップポジション -14.04
バランサ
バランサマップポジション
プライマー配列 IntRev:CGCGGATTCTCTATCAATAG,ExtFwd:GGCCTGCCTTCCTGACATGT,IntFwd:ATCCTGGAGCTGGCGAGTTA,ExtRev:GACTGTAAACGCGCAGAGTC
変異体送付先
寄託者 Dr. S. Mitani/NBRP
文献  論文登録
Law W, Wuescher LM, Ortega A, Hapiak VM, Komuniecki PR, Komuniecki R.
Heterologous Expression in Remodeled C. elegans: A Platform for Monoaminergic Agonist Identification and Anthelmintic Screening.
PLoS Pathog. 2015 11(4) e1004794 
[ PubMed ID = 25928899 ] [ RRCの論文情報 ]

Gomez-Amaro RL, Valentine ER, Carretero M, LeBoeuf SE, Rangaraju S, Broaddus CD, Solis GM, Williamson JR, Petrascheck M.
Measuring Food Intake and Nutrient Absorption in Caenorhabditis elegans.
Genetics 2015 200(2) 443-54 
[ PubMed ID = 25903497 ] [ RRCの論文情報 ]

Tatum MC, Ooi FK, Chikka MR, Chauve L, Martinez-Velazquez LA, Steinbusch HW, Morimoto RI, Prahlad V.
Neuronal serotonin release triggers the heat shock response in C. elegans in the absence of temperature increase.
Curr. Biol. 2015 25(2) 163-74 
[ PubMed ID = 25557666 ] [ RRCの論文情報 ]

Yemini E, Jucikas T, Grundy LJ, Brown AE, Schafer WR.
A database of Caenorhabditis elegans behavioral phenotypes.
Nat. Methods 2013 10(9) 877-9 
[ PubMed ID = 23852451 ] [ RRCの論文情報 ]

Yu H, Aleman-Meza B, Gharib S, Labocha MK, Cronin CJ, Sternberg PW, Zhong W.
Systematic profiling of Caenorhabditis elegans locomotive behaviors reveals additional components in G-protein Gαq signaling.
Proc. Natl. Acad. Sci. U.S.A. 2013 110(29) 11940-5 
[ PubMed ID = 23818641 ] [ RRCの論文情報 ]

Brown AE, Yemini EI, Grundy LJ, Jucikas T, Schafer WR.
A dictionary of behavioral motifs reveals clusters of genes affecting Caenorhabditis elegans locomotion.
Proc. Natl. Acad. Sci. U.S.A. 2013 110(2) 791-6 
[ PubMed ID = 23267063 ] [ RRCの論文情報 ]

Anderson A, Laurenson-Schafer H, Partridge FA, Hodgkin J, McMullan R.
Serotonergic chemosensory neurons modify the C. elegans immune response by regulating G-protein signaling in epithelial cells.
PLoS Pathog. 2013 9(12) e1003787 
[ PubMed ID = 24348250 ] [ RRCの論文情報 ]

Gubert P, Aguiar GC, Mourão T, Bridi JC, Barros AG, Soares FA, Romano-Silva MA.
Behavioral and metabolic effects of the atypical antipsychotic ziprasidone on the nematode Caenorhabditis elegans.
PLoS ONE 2013 8(9) e74780 
[ PubMed ID = 24069346 ] [ RRCの論文情報 ]

Song BM, Faumont S, Lockery S, Avery L.
Recognition of familiar food activates feeding via an endocrine serotonin signal in Caenorhabditis elegans.
Elife 2013 2 e00329 
[ PubMed ID = 23390589 ] [ RRCの論文情報 ]

Cunningham KA, Hua Z, Srinivasan S, Liu J, Lee BH, Edwards RH, Ashrafi K.
AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans.
Cell Metab. 2012 16(1) 113-21 
[ PubMed ID = 22768843 ] [ RRCの論文情報 ]

Song BM, Avery L.
Serotonin activates overall feeding by activating two separate neural pathways in Caenorhabditis elegans.
J Neurosci. 2012 32(6) 1920-31 
[ PubMed ID = 22323705 ] [ RRCの論文情報 ]

Wang Y, Tang L, Feng X, Du W, Liu BF.
Ethanol interferes with gustatory plasticity in Caenorhabditis elegans.
Neurosci. Res. 2011 71(4) 341-7 
[ PubMed ID = 21889959 ] [ RRCの論文情報 ]

Vidal-Gadea A, Topper S, Young L, Crisp A, Kressin L, Elbel E, Maples T, Brauner M, Erbguth K, Axelrod A, Gottschalk A, Siegel D, Pierce-Shimomura JT.
Caenorhabditis elegans selects distinct crawling and swimming gaits via dopamine and serotonin.
Proc. Natl. Acad. Sci. U.S.A. 2011 108(42) 17504-9 
[ PubMed ID = 21969584 ] [ RRCの論文情報 ]

Harris G, Korchnak A, Summers P, Hapiak V, Law WJ, Stein AM, Komuniecki P, Komuniecki R.
Dissecting the serotonergic food signal stimulating sensory-mediated aversive behavior in C. elegans.
PLoS ONE 2011 6(7) e21897 
[ PubMed ID = 21814562 ] [ RRCの論文情報 ]

Govorunova EG, Moussaif M, Kullyev A, Nguyen KC, McDonald TV, Hall DH, Sze JY.
A homolog of FHM2 is involved in modulation of excitatory neurotransmission by serotonin in C. elegans.
PLoS ONE 2010 5(4) e10368 
[ PubMed ID = 20442779 ] [ RRCの論文情報 ]

Donohoe DR, Jarvis RA, Weeks K, Aamodt EJ, Dwyer DS.
Behavioral adaptation in C. elegans produced by antipsychotic drugs requires serotonin and is associated with calcium signaling and calcineurin inhibition.
Neurosci. Res. 2009 64(3) 280-9 
[ PubMed ID = 19447297 ] [ RRCの論文情報 ]

Anyanful A, Easley KA, Benian GM, Kalman D.
Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity.
Cell Host Microbe 2009 5(5) 450-62 
[ PubMed ID = 19454349 ] [ RRCの論文情報 ]

Harris GP, Hapiak VM, Wragg RT, Miller SB, Hughes LJ, Hobson RJ, Steven R, Bamber B, Komuniecki RW.
Three distinct amine receptors operating at different levels within the locomotory circuit are each essential for the serotonergic modulation of chemosensation in Caenorhabditis elegans.
J Neurosci. 2009 29(5) 1446-56 
[ PubMed ID = 19193891 ] [ RRCの論文情報 ]

Hapiak VM, Hobson RJ, Hughes L, Smith K, Harris G, Condon C, Komuniecki P, Komuniecki RW.
Dual excitatory and inhibitory serotonergic inputs modulate egg laying in Caenorhabditis elegans.
Genetics 2009 181(1) 153-63 
[ PubMed ID = 19001289 ] [ RRCの論文情報 ]

Ward A, Walker VJ, Feng Z, Xu XZ.
Cocaine modulates locomotion behavior in C. elegans.
PLoS ONE 2009 4(6) e5946 
[ PubMed ID = 19536276 ] [ RRCの論文情報 ]

Srinivasan S, Sadegh L, Elle IC, Christensen AG, Faergeman NJ, Ashrafi K.
Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms.
Cell Metab. 2008 7(6) 533-44 
[ PubMed ID = 18522834 ] [ RRCの論文情報 ]

You YJ, Kim J, Raizen DM, Avery L.
Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: a model for satiety.
Cell Metab. 2008 7(3) 249-57 
[ PubMed ID = 18316030 ] [ RRCの論文情報 ]

Wragg RT, Hapiak V, Miller SB, Harris GP, Gray J, Komuniecki PR, Komuniecki RW.
Tyramine and octopamine independently inhibit serotonin-stimulated aversive behaviors in Caenorhabditis elegans through two novel amine receptors.
J Neurosci. 2007 27(49) 13402-12 
[ PubMed ID = 18057198 ] [ RRCの論文情報 ]

Petrascheck M, Ye X, Buck LB.
An antidepressant that extends lifespan in adult Caenorhabditis elegans.
Nature 2007 450(7169) 553-6 
[ PubMed ID = 18033297 ] [ RRCの論文情報 ]

Chase DL, Koelle MR.
Biogenic amine neurotransmitters in C. elegans.
WormBook 2007  1-15 
[ PubMed ID = 18050501 ] [ RRCの論文情報 ]

Carre-Pierrat M, Baillie D, Johnsen R, Hyde R, Hart A, Granger L, Ségalat L.
Characterization of the Caenorhabditis elegans G protein-coupled serotonin receptors.
Invert. Neurosci. 2006 6(4) 189-205 
[ PubMed ID = 17082916 ] [ RRCの論文情報 ]

Hobson RJ, Hapiak VM, Xiao H, Buehrer KL, Komuniecki PR, Komuniecki RW.
SER-7, a Caenorhabditis elegans 5-HT7-like receptor, is essential for the 5-HT stimulation of pharyngeal pumping and egg laying.
Genetics 2006 172(1) 159-69 
[ PubMed ID = 16204223 ] [ RRCの論文情報 ]