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AVAILABLE MUTANTS (ISOLATED)
 変異体 To English >>
 
Record No. 1320
対立遺伝子 tm1320
Sequence Name ZK1128.8
CGC Name ZK1128.8
Worm Base 対立遺伝子 tm1320
CGC Name ZK1128.8
Sequence ZK1128.8
表現型 homozygous viable. Dr. G. Hermann: WT gut granules. Dr. H.C. Korswagen: QL and QR daughter cells, HSN migration defects, polarity of V5 division defects, similar to egl-20. Dr. S. Shaham: no obvious defects in glia development. Dr. H. Sawa: non-Psa.
変異部位 1190/1191-A-1731/1732 (541 bp deletion + 1 bp insertion)
染色体
遺伝子構造 complement(join(1289..1558, 1681..1825, 1874..2019, 2073..2075))
マップポジション
バランサ
バランサマップポジション
プライマー配列 IntFwd:CGACGCCAGTTTGACTGCCA,ExtFwd:CTTGCTCTGTAGGCCATCGA,IntRev:TGAACACAGGCTACGACGCT,ExtRev:TAACATGGGAATGCTCGCCT
変異体送付先
寄託者 Dr. S. Mitani/NBRP
文献  論文登録
Bai Z, Grant BD.
A TOCA/CDC-42/PAR/WAVE functional module required for retrograde endocytic recycling.
Proc. Natl. Acad. Sci. U.S.A. 2015 112(12) E1443-52 
[ PubMed ID = 25775511 ] [ RRCの論文情報 ]

de Groot RE, Rappel SB, Lorenowicz MJ, Korswagen HC.
Protein kinase CK2 is required for Wntless internalization and Wnt secretion.
Cell. Signal. 2014 26(12) 2601-5 
[ PubMed ID = 25178265 ] [ RRCの論文情報 ]

de Groot RE, Ganji RS, Bernatik O, Lloyd-Lewis B, Seipel K, Šedová K, Zdráhal Z, Dhople VM, Dale TC, Korswagen HC, Bryja V.
Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway.
Sci Signal 2014 7(317) ra26 
[ PubMed ID = 24643799 ] [ RRCの論文情報 ]

Lorenowicz MJ, Macurkova M, Harterink M, Middelkoop TC, de Groot R, Betist MC, Korswagen HC.
Inhibition of late endosomal maturation restores Wnt secretion in Caenorhabditis elegans vps-29 retromer mutants.
Cell. Signal. 2014 26(1) 19-31 
[ PubMed ID = 24056045 ] [ RRCの論文情報 ]

Ji N, Middelkoop TC, Mentink RA, Betist MC, Tonegawa S, Mooijman D, Korswagen HC, van Oudenaarden A.
Feedback control of gene expression variability in the Caenorhabditis elegans Wnt pathway.
Cell 2013 155(4) 869-80 
[ PubMed ID = 24209624 ] [ RRCの論文情報 ]

Cruciat CM, Dolde C, de Groot RE, Ohkawara B, Reinhard C, Korswagen HC, Niehrs C.
RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling.
Science 2013 339(6126) 1436-41 
[ PubMed ID = 23413191 ] [ RRCの論文情報 ]

Oikonomou G, Perens EA, Lu Y, Shaham S.
Some, but not all, retromer components promote morphogenesis of C. elegans sensory compartments.
Dev. Biol. 2012 362(1) 42-9 
[ PubMed ID = 22138055 ] [ RRCの論文情報 ]

Dang H, Klokk TI, Schaheen B, McLaughlin BM, Thomas AJ, Durns TA, Bitler BG, Sandvig K, Fares H.
Derlin-dependent retrograde transport from endosomes to the Golgi apparatus.
Traffic 2011 12(10) 1417-31 
[ PubMed ID = 21722281 ] [ RRCの論文情報 ]

Harterink M, Port F, Lorenowicz MJ, McGough IJ, Silhankova M, Betist MC, van Weering JR, van Heesbeen RG, Middelkoop TC, Basler K, Cullen PJ, Korswagen HC.
A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion.
Nat. Cell Biol. 2011 13(8) 914-23 
[ PubMed ID = 21725319 ] [ RRCの論文情報 ]

Lu N, Shen Q, Mahoney TR, Liu X, Zhou Z.
Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling.
Mol. Biol. Cell 2011 22(3) 354-74 
[ PubMed ID = 21148288 ] [ RRCの論文情報 ]

Chen D, Xiao H, Zhang K, Wang B, Gao Z, Jian Y, Qi X, Sun J, Miao L, Yang C.
Retromer is required for apoptotic cell clearance by phagocytic receptor recycling.
Science 2010 327(5970) 1261-4 
[ PubMed ID = 20133524 ] [ RRCの論文情報 ]

Wassmer T, Attar N, Harterink M, van Weering JR, Traer CJ, Oakley J, Goud B, Stephens DJ, Verkade P, Korswagen HC, Cullen PJ.
The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network.
Dev. Cell 2009 17(1) 110-22 
[ PubMed ID = 19619496 ] [ RRCの論文情報 ]

Coudreuse DY, Roël G, Betist MC, Destrée O, Korswagen HC.
Wnt gradient formation requires retromer function in Wnt-producing cells.
Science 2006 312(5775) 921-4 
[ PubMed ID = 16645052 ] [ RRCの論文情報 ]

Prasad BC, Clark SG.
Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans.
Development 2006 133(9) 1757-66 
[ PubMed ID = 16571624 ] [ RRCの論文情報 ]

Hermann GJ, Schroeder LK, Hieb CA, Kershner AM, Rabbitts BM, Fonarev P, Grant BD, Priess JR.
Genetic analysis of lysosomal trafficking in Caenorhabditis elegans.
Mol. Biol. Cell 2005 16(7) 3273-88 
[ PubMed ID = 15843430 ] [ RRCの論文情報 ]