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AVAILABLE MUTANTS (ISOLATED)
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Record No. 1133
対立遺伝子 tm1133
Sequence Name ZK1248.14
CGC Name fzo-1
Worm Base 対立遺伝子 tm1133
CGC Name fzo-1
Sequence ZK1248.14
表現型 homozygous viable. Dr. J-C. Martinou: not hypersensitive to anoxia, a bit slow growth at 20 degree. Dr. Xue: Mol Cell 31, 586 (2008). Dr. T. Oka: J. Biochem. 143, 449 (2008). Dr. H. Sawa: normal embryonic cell division.
変異部位 26031/26032-GTTCAGCCACATTG-26450/26451 (419 bp deletion + 14 bp insertion)
染色体 II
遺伝子構造 complement(join(24019..24100, 24149..24283, 24330..24800, 24846..24957, 25007..26114, 26166..26383, 26435..26560, 26607..26679))
マップポジション -0.87
バランサ
バランサマップポジション
プライマー配列 ExtFwd:GCTCTGTCTGCTCACGGTAA,IntFwd:GTCCTGGTGGATTCGTTTAG,ExtRev:CTCATTGCATGTACGGTGTA,IntRev:GAACGGGGGCTTGCTGATTA
変異体送付先
寄託者 Dr. S. Mitani/NBRP
文献  論文登録
Köhler F, Müller-Rischart AK, Conradt B, Rolland SG.
The loss of LRPPRC function induces the mitochondrial unfolded protein response.
Aging (Albany NY) 2015 7(9) 701-17 
[ PubMed ID = 26412102 ] [ RRCの論文情報 ]

Jiang HC, Hsu JM, Yen CP, Chao CC, Chen RH, Pan CL.
Neural activity and CaMKII protect mitochondria from fragmentation in aging Caenorhabditis elegans neurons.
Proc. Natl. Acad. Sci. U.S.A. 2015 112(28) 8768-73 
[ PubMed ID = 26124107 ] [ RRCの論文情報 ]

Luz AL, Rooney JP, Kubik LL, Gonzalez CP, Song DH, Meyer JN.
Mitochondrial Morphology and Fundamental Parameters of the Mitochondrial Respiratory Chain Are Altered in Caenorhabditis elegans Strains Deficient in Mitochondrial Dynamics and Homeostasis Processes.
PLoS ONE 2015 10(6) e0130940 
[ PubMed ID = 26106885 ] [ RRCの論文情報 ]

Ackema KB, Hench J, Böckler S, Wang SC, Sauder U, Mergentaler H, Westermann B, Bard F, Frank S, Spang A.
The small GTPase Arf1 modulates mitochondrial morphology and function.
EMBO J. 2014 33(22) 2659-75 
[ PubMed ID = 25190516 ] [ RRCの論文情報 ]

Rolland SG, Motori E, Memar N, Hench J, Frank S, Winklhofer KF, Conradt B.
Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion.
Proc. Natl. Acad. Sci. U.S.A. 2013 110(32) E2967-76 
[ PubMed ID = 23878239 ] [ RRCの論文情報 ]

Yu H, Aleman-Meza B, Gharib S, Labocha MK, Cronin CJ, Sternberg PW, Zhong W.
Systematic profiling of Caenorhabditis elegans locomotive behaviors reveals additional components in G-protein Gαq signaling.
Proc. Natl. Acad. Sci. U.S.A. 2013 110(29) 11940-5 
[ PubMed ID = 23818641 ] [ RRCの論文情報 ]

Ohba Y, Sakuragi T, Kage-Nakadai E, Tomioka NH, Kono N, Imae R, Inoue A, Aoki J, Ishihara N, Inoue T, Mitani S, Arai H.
Mitochondria-type GPAT is required for mitochondrial fusion.
EMBO J. 2013 32(9) 1265-79 
[ PubMed ID = 23572076 ] [ RRCの論文情報 ]

Bess AS, Crocker TL, Ryde IT, Meyer JN.
Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans.
Nucleic Acids Res. 2012 40(16) 7916-31 
[ PubMed ID = 22718972 ] [ RRCの論文情報 ]

Johnson D, Allman E, Nehrke K.
Regulation of acid-base transporters by reactive oxygen species following mitochondrial fragmentation.
Am. J. Physiol., Cell Physiol. 2012 302(7) C1045-54 
[ PubMed ID = 22237403 ] [ RRCの論文情報 ]

Yasuda K, Hartman PS, Ishii T, Suda H, Akatsuka A, Shoyama T, Miyazawa M, Ishii N.
Interrelationships between mitochondrial fusion, energy metabolism and oxidative stress during development in Caenorhabditis elegans.
Biochem. Biophys. Res. Commun. 2011 404(3) 751-5 
[ PubMed ID = 21144829 ] [ RRCの論文情報 ]

Johnson D, Nehrke K.
Mitochondrial fragmentation leads to intracellular acidification in Caenorhabditis elegans and mammalian cells.
Mol. Biol. Cell 2010 21(13) 2191-201 
[ PubMed ID = 20444981 ] [ RRCの論文情報 ]

Rolland SG, Lu Y, David CN, Conradt B.
The BCL-2-like protein CED-9 of C. elegans promotes FZO-1/Mfn1,2- and EAT-3/Opa1-dependent mitochondrial fusion.
J Cell Biol. 2009 186(4) 525-40 
[ PubMed ID = 19704021 ] [ RRCの論文情報 ]

Breckenridge DG, Kang BH, Xue D.
Bcl-2 proteins EGL-1 and CED-9 do not regulate mitochondrial fission or fusion in Caenorhabditis elegans.
Curr. Biol. 2009 19(9) 768-73 
[ PubMed ID = 19327994 ] [ RRCの論文情報 ]

Tan FJ, Husain M, Manlandro CM, Koppenol M, Fire AZ, Hill RB.
CED-9 and mitochondrial homeostasis in C. elegans muscle.
J Cell Sci. 2008 121(Pt 20) 3373-82 
[ PubMed ID = 18827010 ] [ RRCの論文情報 ]

Breckenridge DG, Kang BH, Kokel D, Mitani S, Staehelin LA, Xue D.
Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9.
Mol. Cell 2008 31(4) 586-97 
[ PubMed ID = 18722182 ] [ RRCの論文情報 ]

Kanazawa T, Zappaterra MD, Hasegawa A, Wright AP, Newman-Smith ED, Buttle KF, McDonald K, Mannella CA, van der Bliek AM.
The C. elegans Opa1 homologue EAT-3 is essential for resistance to free radicals.
PLoS Genet. 2008 4(2) e1000022 
[ PubMed ID = 18454199 ] [ RRCの論文情報 ]