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AVAILABLE MUTANTS (ISOLATED)
 変異体 To English >>
 
Record No. 1108
対立遺伝子 tm1108
Sequence Name T12E12.4
CGC Name drp-1
Worm Base 対立遺伝子 tm1108
CGC Name drp-1
Sequence T12E12.4
表現型 homozygous viable. Dr. H-S. Koo: embryonic lethality of 15%, L1-L3 larval arrest of lethality of 60%. Dr. A. van der Bliek: Sma, Gro. normal locomotion. connected mitochondria in muscle and hypodermal cells. Dr. D. Xue: slow growth but not lethal or sterile. Mol Cell, 31, 586 (2008). Dr. J. Kaplan: resistant to aldicarb.
変異部位 1053/1054-CTCCAGCGAACCAGGATT-1477/1478 (425 bp deletion + 18 bp insertion)
染色体 IV
遺伝子構造 join(429..741, 792..1357, 1403..2152, 2269..2419, 2470..2559, 2612..2706, 2758..2874, 2924..2956, 3004..3012)
マップポジション 1.82
バランサ
バランサマップポジション
プライマー配列 ExtFwd:TGAGTAAGTGGCAGGATCGA,IntFwd:CGAAGGCCAAGTAGACTATC,ExtRev:GAGGTTAAGCCCATGCAATA,IntRev:CCCAGTCAGTCATCCGCACT
変異体送付先
寄託者 Dr. S. Mitani/NBRP
文献  論文登録
Lowry J, Yochem J, Chuang CH, Sugioka K, Connolly AA, Bowerman B.
High-Throughput Cloning of Temperature-Sensitive Caenorhabditis elegans Mutants with Adult Syncytial Germline Membrane Architecture Defects.
G3 (Bethesda) 2015 5(11) 2241-55 
[ PubMed ID = 26311651 ] [ RRCの論文情報 ]

Jiang HC, Hsu JM, Yen CP, Chao CC, Chen RH, Pan CL.
Neural activity and CaMKII protect mitochondria from fragmentation in aging Caenorhabditis elegans neurons.
Proc. Natl. Acad. Sci. U.S.A. 2015 112(28) 8768-73 
[ PubMed ID = 26124107 ] [ RRCの論文情報 ]

Luz AL, Rooney JP, Kubik LL, Gonzalez CP, Song DH, Meyer JN.
Mitochondrial Morphology and Fundamental Parameters of the Mitochondrial Respiratory Chain Are Altered in Caenorhabditis elegans Strains Deficient in Mitochondrial Dynamics and Homeostasis Processes.
PLoS ONE 2015 10(6) e0130940 
[ PubMed ID = 26106885 ] [ RRCの論文情報 ]

Ackema KB, Hench J, Böckler S, Wang SC, Sauder U, Mergentaler H, Westermann B, Bard F, Frank S, Spang A.
The small GTPase Arf1 modulates mitochondrial morphology and function.
EMBO J. 2014 33(22) 2659-75 
[ PubMed ID = 25190516 ] [ RRCの論文情報 ]

Regmi SG, Rolland SG, Conradt B.
Age-dependent changes in mitochondrial morphology and volume are not predictors of lifespan.
Aging (Albany NY) 2014 6(2) 118-30 
[ PubMed ID = 24642473 ] [ RRCの論文情報 ]

Shen Q, Yamano K, Head BP, Kawajiri S, Cheung JT, Wang C, Cho JH, Hattori N, Youle RJ, van der Bliek AM.
Mutations in Fis1 disrupt orderly disposal of defective mitochondria.
Mol. Biol. Cell 2014 25(1) 145-59 
[ PubMed ID = 24196833 ] [ RRCの論文情報 ]

Staab TA, Evgrafov O, Knowles JA, Sieburth D.
Regulation of synaptic nlg-1/neuroligin abundance by the skn-1/Nrf stress response pathway protects against oxidative stress.
PLoS Genet. 2014 10(1) e1004100 
[ PubMed ID = 24453991 ] [ RRCの論文情報 ]

Rolland SG, Motori E, Memar N, Hench J, Frank S, Winklhofer KF, Conradt B.
Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion.
Proc. Natl. Acad. Sci. U.S.A. 2013 110(32) E2967-76 
[ PubMed ID = 23878239 ] [ RRCの論文情報 ]

Yu H, Aleman-Meza B, Gharib S, Labocha MK, Cronin CJ, Sternberg PW, Zhong W.
Systematic profiling of Caenorhabditis elegans locomotive behaviors reveals additional components in G-protein Gαq signaling.
Proc. Natl. Acad. Sci. U.S.A. 2013 110(29) 11940-5 
[ PubMed ID = 23818641 ] [ RRCの論文情報 ]

Staab TA, Griffen TC, Corcoran C, Evgrafov O, Knowles JA, Sieburth D.
The conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegans.
PLoS Genet. 2013 9(3) e1003354 
[ PubMed ID = 23555279 ] [ RRCの論文情報 ]

Bess AS, Leung MC, Ryde IT, Rooney JP, Hinton DE, Meyer JN.
Effects of mutations in mitochondrial dynamics-related genes on the mitochondrial response to ultraviolet C radiation in developing Caenorhabditis elegans.
Worm 2013 2(1) e23763 
[ PubMed ID = 24058863 ] [ RRCの論文情報 ]

Bess AS, Crocker TL, Ryde IT, Meyer JN.
Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans.
Nucleic Acids Res. 2012 40(16) 7916-31 
[ PubMed ID = 22718972 ] [ RRCの論文情報 ]

Lu Y, Rolland SG, Conradt B.
A molecular switch that governs mitochondrial fusion and fission mediated by the BCL2-like protein CED-9 of Caenorhabditis elegans.
Proc. Natl. Acad. Sci. U.S.A. 2011 108(41) E813-22 
[ PubMed ID = 21949250 ] [ RRCの論文情報 ]

Yang CC, Chen D, Lee SS, Walter L.
The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity.
Aging Cell 2011 10(4) 724-8 
[ PubMed ID = 21463460 ] [ RRCの論文情報 ]

Abdelwahid E, Rolland S, Teng X, Conradt B, Hardwick JM, White K.
Mitochondrial involvement in cell death of non-mammalian eukaryotes.
Biochim. Biophys. Acta 2011 1813(4) 597-607 
[ PubMed ID = 20950655 ] [ RRCの論文情報 ]

Head BP, Zulaika M, Ryazantsev S, van der Bliek AM.
A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans.
Mol. Biol. Cell 2011 22(6) 831-41 
[ PubMed ID = 21248201 ] [ RRCの論文情報 ]

Earls LR, Hacker ML, Watson JD, Miller DM 3rd.
Coenzyme Q protects Caenorhabditis elegans GABA neurons from calcium-dependent degeneration.
Proc. Natl. Acad. Sci. U.S.A. 2010 107(32) 14460-5 
[ PubMed ID = 20663955 ] [ RRCの論文情報 ]

Johnson D, Nehrke K.
Mitochondrial fragmentation leads to intracellular acidification in Caenorhabditis elegans and mammalian cells.
Mol. Biol. Cell 2010 21(13) 2191-201 
[ PubMed ID = 20444981 ] [ RRCの論文情報 ]

Rolland SG, Lu Y, David CN, Conradt B.
The BCL-2-like protein CED-9 of C. elegans promotes FZO-1/Mfn1,2- and EAT-3/Opa1-dependent mitochondrial fusion.
J. Cell Biol. 2009 186(4) 525-40 
[ PubMed ID = 19704021 ] [ RRCの論文情報 ]

Breckenridge DG, Kang BH, Xue D.
Bcl-2 proteins EGL-1 and CED-9 do not regulate mitochondrial fission or fusion in Caenorhabditis elegans.
Curr. Biol. 2009 19(9) 768-73 
[ PubMed ID = 19327994 ] [ RRCの論文情報 ]

Breckenridge DG, Kang BH, Kokel D, Mitani S, Staehelin LA, Xue D.
Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9.
Mol. Cell 2008 31(4) 586-97 
[ PubMed ID = 18722182 ] [ RRCの論文情報 ]