Home > 分離済み変異体 > tm985

分離済み変異体

Allele Name		tm985
Allele Type		通常株
Sequence Name		T22H2.6
Gene Name		pgrn-1
Worm Base	Allele Name	tm985
	Gene Name	pgrn-1
	Sequence	T22H2.6
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		13245/13246-13592/13593 (347 bp deletion)
Chromosome		I
Putative gene structure		join(13294..13572, 13820..14236, 14686..14931, 15122..15256)
Map position		9.59
Balancer
Map position of balancer
Sequence of primers		IntRev:GCCTCGAAGGTAACTCACGT,IntFwd:GACCAAGTTGGCGTCAGAAA,ExtRev:GCTTGTAGGTGAAGCTGCCT,ExtFwd:ACTCGGAGAAATAGGACCAA
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Doyle JJ, Maios C, Vrancx C, Duhaime S, Chitramuthu B, Bennett HPJ, Bateman A, Parker JA. Chemical and genetic rescue of in vivo progranulin-deficient lysosomal and autophagic defects. Proc Natl Acad Sci U S A 2021 118(25)   [ PubMed ID = 34140407 ] [ RRC reference ] Butler VJ, Gao F, Corrales CI, Cortopassi WA, Caballero B, Vohra M, Ashrafi K, Cuervo AM, Jacobson MP, Coppola G, Kao AW. Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response. PLoS Genet 2019 15(8) e1008295  [ PubMed ID = 31398187 ] [ RRC reference ] Kao AW, Eisenhut RJ, Martens LH, Nakamura A, Huang A, Bagley JA, Zhou P, de Luis A, Neukomm LJ, Cabello J, Farese RV Jr, Kenyon C. A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells. Proc Natl Acad Sci U S A 2011 108(11) 4441-6  [ PubMed ID = 21368173 ] [ RRC reference ] Judy ME, Nakamura A, Huang A, Grant H, McCurdy H, Weiberth KF, Gao F, Coppola G, Kenyon C, Kao AW. A shift to organismal stress resistance in programmed cell death mutants. PLoS Genet 2013 9(9) e1003714  [ PubMed ID = 24068943 ] [ RRC reference ] Salazar DA, Butler VJ, Argouarch AR, Hsu TY, Mason A, Nakamura A, McCurdy H, Cox D, Ng R, Pan G, Seeley WW, Miller BL, Kao AW. The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels. J Neurosci 2015 35(25) 9315-28  [ PubMed ID = 26109656 ] [ RRC reference ] Tauffenberger A, Chitramuthu BP, Bateman A, Bennett HP, Parker JA. Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models. Hum Mol Genet 2013 22(4) 782-94  [ PubMed ID = 23172908 ] [ RRC reference ]