Home > 分離済み変異体 > tm917

分離済み変異体

Allele Name		tm917
Balance		Not Required
OutCross		Not Accepted
Sequence Name		Y48E1B.13
Gene Name		csp-1
Worm Base	Allele Name	tm917
	Gene Name	csp-1
	Sequence	Y48E1B.13
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr. R.H. Horvitz: No extra cells in anterior pharynx. Dr. S. Shaham: no defects in somatic cell death.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		76885/76886-77634/77635 (749 bp deletion)
Chromosome		II
Putative gene structure		join(76378..76614, 77078..77206, 77454..77803, 78165..78306, 78570..78708, 79626..79879, 79924..80131, 80291..80596, 80631..80692, 80817..80918)
Map position		18.6
Balancer
Map position of balancer
Sequence of primers		ExtRev:CCCAGACTCGATTGTACATC,IntRev:GTAACAGGGGGTGTGGATAT,ExtFwd:CGCCGGACGAAAGTAAGGCT,IntFwd:TGTGGCACCGGCTTATGTCC
Distributed lab
Depositor		Dr. S. Mitani
References		Please submit your publication Flowers S, Kothari R, Torres Cleuren YN, Alcorn MR, Ewe CK, Alok G, Fiallo SL, Joshi PM, Rothman JH. Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways. Elife 2023 12   [ PubMed ID = 37782016 ] [ RRC reference ] Denning DP, Hatch V, Horvitz HR. Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans. PLoS Genet 2013 9(3) e1003341  [ PubMed ID = 23505386 ] [ RRC reference ] Chen L, McCloskey T, Joshi PM, Rothman JH. ced-4 and proto-oncogene tfg-1 antagonistically regulate cell size and apoptosis in C. elegans. Curr Biol 2008 18(14) 1025-33  [ PubMed ID = 18635357 ] [ RRC reference ] Abraham MC, Lu Y, Shaham S. A morphologically conserved nonapoptotic program promotes linker cell death in Caenorhabditis elegans. Dev Cell 2007 12(1) 73-86  [ PubMed ID = 17199042 ] [ RRC reference ]