分離済み変異体

tm861

Allele Nametm861
BalanceNot Required
OutCrossNot Accepted
Sequence NameC27B7.8
Gene Namerap-1
Worm BaseAllele Name tm861
Gene Name rap-1
Sequence C27B7.8
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable.Dr. O. Blacque: could not examine Dyf phenotype.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 28495/28496-28995/28996 (500 bp deletion)
ChromosomeIV
Putative gene structurecomplement(join(27359..27460, 28236..28376, 28425..28565, 28615..28671, 29074..29142, 29192..29248))
Map position4
Balancer
Map position of balancer
Sequence of primersExtFwd:TATTTGACGAACGAGGTCGT,IntFwd:GGTCGTAGAACACCTGAAAT,IntRev:CCAAGCATCAACAACACCAT,ExtRev:GGTCGTCGATTGCAGGGAAT
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Rodriguez-Polanco WR, Norris A, Velasco AB, Gleason AM, Grant BD.
Syndapin and GTPase RAP-1 control endocytic recycling via RHO-1 and non-muscle myosin II.
Curr Biol 2023 33(22) 4844-4856.e5 
[ PubMed ID = 37832552 ] [ RRC reference ]

Reiner DJ, Lundquist EA.
Small GTPases.
WormBook 2018 2018 1-65 
[ PubMed ID = 27218782 ] [ RRC reference ]

Fay DS, Polley SR, Kuang J, Kuzmanov A, Hazel JW, Mani K, Veo BL, Yochem J.
A regulatory module controlling pharyngeal development and function in Caenorhabditis elegans.
Genetics 2012 191(3) 827-43 
[ PubMed ID = 22542967 ] [ RRC reference ]

Frische EW, Pellis-van Berkel W, van Haaften G, Cuppen E, Plasterk RH, Tijsterman M, Bos JL, Zwartkruis FJ.
RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans.
EMBO J 2007 26(24) 5083-92 
[ PubMed ID = 17989692 ] [ RRC reference ]