分離済み変異体

tm788

Allele Name

tm788

Balance

Not Required

OutCross

Not Accepted

Sequence Name

T18D3.3

Gene Name

cdf-2

Worm Base

Allele Name

tm788

Gene Name

cdf-2

Sequence

T18D3.3

Phenotype

homozygous viable

Mutation site

28668/28669-AAAGCAATATAAATTTTAAAAGCAATACCTCTCCGATTGCTATCATGTGAATCTGTTGAGTCAGCTTC-29472/29473 (804 bp deletion +69 bp insertion)

Chromosome

Putative gene structure

complement(join(26870..27043, 27088..27194, 27506..27611, 27693..27876, 28147..28300, 28348..28557, 28625..28737, 29176..29276))

Map position

7.11

Balancer

Map position of balancer

Sequence of primers

ExtRev:GCTCTTCCTGCCATTTTGCT,ExtFwd:GCTCGGACGTTGATGTTATC,IntRev:CCACACAACCACTTTAGCGA,IntFwd:CCGTTGCCACCACCATGAGA

Distributed lab

Depositor

Dr. S. Mitani/NBRP

References

Please submit your publication

Dejima K, Imae R, Suehiro Y, Yoshida K, Mitani S.
An endomembrane zinc transporter negatively regulates systemic RNAi in Caenorhabditis elegans.
iScience 2023 26(6) 106930
[ PubMed ID = 37305693 ] [ RRC reference ]

Sharma AK, Finney L, Vogt S, Vatamaniuk OK, Kim S.
Cadmium alters whole animal ionome and promotes the re-distribution of iron in intestinal cells of Caenorhabditis elegans.
Front Physiol 2023 14 1258540
[ PubMed ID = 37822680 ] [ RRC reference ]

Earley BJ, Cubillas C, Warnhoff K, Ahmad R, Alcantar A, Lyon MD, Schneider DL, Kornfeld K.
Cadmium hijacks the high zinc response by binding and activating the HIZR-1 nuclear receptor.
Proc Natl Acad Sci U S A 2021 118(42)
[ PubMed ID = 34649987 ] [ RRC reference ]

Hu Y, Wang Y, Wang X, Wu X, Fu L, Liu X, Wen Y, Sheng J, Zhang J.
The role of cation diffusion facilitator CDF-1 in lipid metabolism in Caenorhabditis elegans.
G3 (Bethesda) 2021 11(7)
[ PubMed ID = 33871589 ] [ RRC reference ]

Luallen RJ, Bakowski MA, Troemel ER.
Characterization of microsporidia-induced developmental arrest and a transmembrane leucine-rich repeat protein in Caenorhabditis elegans.
PLoS One 2015 10(4) e0124065
[ PubMed ID = 25874557 ] [ RRC reference ]

Roh HC, Collier S, Deshmukh K, Guthrie J, Robertson JD, Kornfeld K.
ttm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasis.
PLoS Genet 2013 9(5) e1003522
[ PubMed ID = 23717214 ] [ RRC reference ]

Roh HC, Collier S, Guthrie J, Robertson JD, Kornfeld K.
Lysosome-related organelles in intestinal cells are a zinc storage site in C. elegans.
Cell Metab 2012 15(1) 88-99
[ PubMed ID = 22225878 ] [ RRC reference ]

Murphy JT, Bruinsma JJ, Schneider DL, Collier S, Guthrie J, Chinwalla A, Robertson JD, Mardis ER, Kornfeld K.
Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans.
PLoS Genet 2011 7(3) e1002013
[ PubMed ID = 21455490 ] [ RRC reference ]

Davis DE, Roh HC, Deshmukh K, Bruinsma JJ, Schneider DL, Guthrie J, Robertson JD, Kornfeld K.
The cation diffusion facilitator gene cdf-2 mediates zinc metabolism in Caenorhabditis elegans.
Genetics 2009 182(4) 1015-33
[ PubMed ID = 19448268 ] [ RRC reference ]