Home > 分離済み変異体 > tm764

分離済み変異体

Allele Name		tm764
Balance		Not Required
OutCross		Not Accepted
Sequence Name		F18C5.2
Gene Name		wrn-1
Worm Base	Allele Name	tm764
	Gene Name	wrn-1
	Sequence	F18C5.2
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr. S. Ahmed: Not hypersensitive to ionizing radiation. Dr. H-S. Koo: hypersensitive to ionizing radiation at L1 stage.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		9579/9580-10035/10036 (456 bp deletion)
Chromosome		II
Putative gene structure		join(8186..8300, 8357..8413, 8461..9238, 9284..9354, 9406..9786, 10106..10191, 10498..10580, 10631..10847, 10897..11222, 11270..11369, 11419..11543, 11595..11727, 11772..11864, 11912..12071, 12121..12356)
Map position		-0.13
Balancer
Map position of balancer
Sequence of primers		ExtFwd:GATGACGATCTACCATCTAC,ExtRev:TCCAACGGTTGTCAGAACCA,IntFwd:CGCCCGGGATCTGTGAATGA,IntRev:CTCGAGTTGTCTTAGCATCA
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Suehiro Y, Yoshina S, Motohashi T, Iwata S, Dejima K, Mitani S. Efficient collection of a large number of mutations by mutagenesis of DNA damage response defective animals. Sci Rep 2021 11(1) 7630  [ PubMed ID = 33828169 ] [ RRC reference ] Lee SJ, Gartner A, Hyun M, Ahn B, Koo HS. The Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks. PLoS Genet 2010 6(1) e1000801  [ PubMed ID = 20062519 ] [ RRC reference ] Ahmed S. Uncoupling of pathways that promote postmitotic life span and apoptosis from replicative immortality of Caenorhabditis elegans germ cells. Aging Cell 2006 5(6) 559-63  [ PubMed ID = 17081157 ] [ RRC reference ]