Home > 分離済み変異体 > tm677

分離済み変異体

Allele Name		tm677
Allele Type		バランス済
Sequence Name		C01G8.5
Gene Name		erm-1
Worm Base	Allele Name	tm677
	Gene Name	erm-1
	Sequence	C01G8.5
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		lethal or sterile. Dr. V. Maricq: maternal effect lethal with defects in gonad and intestine development., Dr. V. Gobel: Dev. Cell 6, 865-873 (2004). Dr. M. Hengartner: defects in DTC migration but not in corpse removal in the L1 head and adult gonad.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		14065/14066-TT-15037/15038 (972 bp deletion + 2 bp insertion)
Chromosome		I
Putative gene structure		complement(join(12105..12197, 12726..12892, 12970..13075, 13609..13956, 14039..14218, 14958..15140, 15189..15348, 15671..15825, 17500..17700, 17942..18025, 19001..19015))
Map position		-0.16
Balancer		hT2 bli-4(e937) let-? qIs48]
Map position of balancer
Sequence of primers		IntFwd:CACATTCTGATCAGCGTCAT,IntRev:CAACTACACGTGAACAAGCT,ExtRev:GTGGGCAGATCATCGTGCAA,ExtFwd:CAACTCGTGTTGTGGCACAT
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Sepers JJ, Ramalho JJ, Kroll JR, Schmidt R, Boxem M. ERM-1 Phosphorylation and NRFL-1 Redundantly Control Lumen Formation in the C. elegans Intestine. Front Cell Dev Biol 2022 10 769862  [ PubMed ID = 35198555 ] [ RRC reference ] Kalichamy SS, Alcantara AV Jr, Kim BS, Park J, Yoon KH, Lee JI. Muscle and epidermal contributions of the structural protein β-spectrin promote hypergravity-induced motor neuron axon defects in C. elegans. Sci Rep 2020 10(1) 21214  [ PubMed ID = 33273580 ] [ RRC reference ] Yang Q, Roiz D, Mereu L, Daube M, Hajnal A. The Invading Anchor Cell Induces Lateral Membrane Constriction during Vulval Lumen Morphogenesis in C. elegans. Dev Cell 2017 42(3) 271-285.e3  [ PubMed ID = 28787593 ] [ RRC reference ] Teulière J, Gally C, Garriga G, Labouesse M, Georges-Labouesse E. MIG-15 and ERM-1 promote growth cone directional migration in parallel to UNC-116 and WVE-1. Development 2011 138(20) 4475-85  [ PubMed ID = 21937599 ] [ RRC reference ] Khan LA, Zhang H, Abraham N, Sun L, Fleming JT, Buechner M, Hall DH, Gobel V. Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux. Nat Cell Biol 2013 15(2) 143-56  [ PubMed ID = 23334498 ] [ RRC reference ] Carberry K, Wiesenfahrt T, Geisler F, Stöcker S, Gerhardus H, Überbach D, Davis W, Jorgensen E, Leube RE, Bossinger O. The novel intestinal filament organizer IFO-1 contributes to epithelial integrity in concert with ERM-1 and DLG-1. Development 2012 139(10) 1851-62  [ PubMed ID = 22510987 ] [ RRC reference ] Bernadskaya YY, Patel FB, Hsu HT, Soto MC. Arp2/3 promotes junction formation and maintenance in the Caenorhabditis elegans intestine by regulating membrane association of apical proteins. Mol Biol Cell 2011 22(16) 2886-99  [ PubMed ID = 21697505 ] [ RRC reference ] Haag A, Gutierrez P, Bühler A, Walser M, Yang Q, Langouët M, Kradolfer D, Fröhli E, Herrmann CJ, Hajnal A, Escobar-Restrepo JM. An in vivo EGF receptor localization screen in C. elegans Identifies the Ezrin homolog ERM-1 as a temporal regulator of signaling. PLoS Genet 2014 10(5) e1004341  [ PubMed ID = 24785082 ] [ RRC reference ] Norris AD, Dyer JO, Lundquist EA. The Arp2/3 complex, UNC-115/abLIM, and UNC-34/Enabled regulate axon guidance and growth cone filopodia formation in Caenorhabditis elegans. Neural Dev 2009 4 38  [ PubMed ID = 19799769 ] [ RRC reference ] Göbel V, Barrett PL, Hall DH, Fleming JT. Lumen morphogenesis in C. elegans requires the membrane-cytoskeleton linker erm-1. Dev Cell 2004 6(6) 865-73  [ PubMed ID = 15177034 ] [ RRC reference ]