Home > 分離済み変異体 > tm6691

分離済み変異体

Allele Name		tm6691
Allele Type		通常株
Sequence Name		T05H10.2
Gene Name		apn-1
Worm Base	Allele Name	tm6691
	Gene Name	apn-1
	Sequence	T05H10.2
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		5188/5189-5384/5385 (196 bp deletion)
Chromosome		II
Putative gene structure		join(5219..5363, 5576..6205, 6257..6672)
Map position		0.66
Balancer
Map position of balancer
Sequence of primers		ExtRev:CCATCGAGACGGTTGTCGTT,IntFwd:TTCTATTCACCACGCCCTGA,ExtFwd:CGCTCGGTTGCAGTATACTT,IntRev:TCATGACGATCGAGCTTCGA
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Yan J, Bhanshali F, Shuzenji C, Mendenhall TT, Taylor SKB, Ermakova G, Cheng X, Bai P, Diwan G, Seraj D, Meyer JN, Sorensen PH, Hartman JH, Taubert S. Eukaryotic Elongation Factor 2 Kinase EFK-1/eEF2K promotes starvation resistance by preventing oxidative damage in C. elegans. Nat Commun 2025 16(1) 1752  [ PubMed ID = 39966347 ] [ RRC reference ] Nicolai MM, Weishaupt AK, Baesler J, Brinkmann V, Wellenberg A, Winkelbeiner N, Gremme A, Aschner M, Fritz G, Schwerdtle T, Bornhorst J. Effects of Manganese on Genomic Integrity in the Multicellular Model Organism Caenorhabditis elegans. Int J Mol Sci 2021 22(20)   [ PubMed ID = 34681565 ] [ RRC reference ] Miyaji M, Hayashi Y, Funakoshi M, Tanaka A, Zhang-Akiyama QM. AP endonuclease EXO-3 deficiency causes developmental delay and abnormal vulval organogenesis, Pvl, through DNA glycosylase-initiated checkpoint activation in Caenorhabditis elegans. Sci Rep 2018 8(1) 16736  [ PubMed ID = 30425296 ] [ RRC reference ] Papaluca A, Wagner JR, Saragovi HU, Ramotar D. UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans. Sci Rep 2018 8(1) 6860  [ PubMed ID = 29717169 ] [ RRC reference ] Papaluca A, Ramotar D. A novel approach using C. elegans DNA damage-induced apoptosis to characterize the dynamics of uptake transporters for therapeutic drug discoveries. Sci Rep 2016 6 36026  [ PubMed ID = 27786254 ] [ RRC reference ] Kato Y, Moriwaki T, Funakoshi M, Zhang-Akiyama QM. Caenorhabditis elegans EXO-3 contributes to longevity and reproduction: differential roles in somatic cells and germ cells. Mutat Res 2015 772 46-54  [ PubMed ID = 25772110 ] [ RRC reference ]