Home > 分離済み変異体 > tm6659

分離済み変異体

Allele Name		tm6659
Allele Type		通常株
Sequence Name		R13H8.1
Gene Name		daf-16
Worm Base	Allele Name	tm6659
	Gene Name	daf-16
	Sequence	R13H8.1
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		3736/3737-4703/4704 (967 bp deletion)
Chromosome		I
Putative gene structure		R13H8.1a=join(14814..15455, 16266..16427, 16590..16771, 16831..17050, 17300..17412, 18083..18356) daf-16f=join([H36N01] 3907..3930, 4169..4259, 4313..4463, [R13H8] 6960..7012, 7657..7802, 8516..8589, 16266..16427, 16590..16771, 16831..17050, 17300..17412, 18083..18356) daf-16b.=join(6409..6653, 6896..7012, 7663..7802, 8516..8589, 16266..16427, 16590..16771, 16831..17050, 17300..17412, 18083..18356)
Map position		5.08
Balancer
Map position of balancer
Sequence of primers		IntFwd:GGGTCGCTCAGAAGTTGATC,ExtFwd:GCATGGGGTCGCTCAGAAGT,IntRev:GACAATAGGCTTGTTGGCCT,ExtRev:CCGTGTGCTTAGTGGACCAA
Distributed lab
Depositor		Dr. S. Mitani
References		Please submit your publication Ham S, Kim SS, Park S, Kwon HC, Ha SG, Bae Y, Lee GY, Lee SV. Combinatorial transcriptomic and genetic dissection of insulin/IGF-1 signaling-regulated longevity in Caenorhabditis elegans. Aging Cell 2024  e14151  [ PubMed ID = 38529797 ] [ RRC reference ] Cuko L, Cale AR, Rambo L, Knoblock ML, Karp X. Distinct daf-16 isoforms regulate specification of vulval precursor cells in Caenorhabditis elegans. MicroPubl Biol 2022 2022   [ PubMed ID = 36575736 ] [ RRC reference ] Zhao Y, Zhang B, Marcu I, Athar F, Wang H, Galimov ER, Chapman H, Gems D. Mutation of daf-2 extends lifespan via tissue-specific effectors that suppress distinct life-limiting pathologies. Aging Cell 2021 20(3) e13324  [ PubMed ID = 33609424 ] [ RRC reference ] Nagashima T, Iino Y, Tomioka M. DAF-16/FOXO promotes taste avoidance learning independently of axonal insulin-like signaling. PLoS Genet 2019 15(7) e1008297  [ PubMed ID = 31323047 ] [ RRC reference ] Franz A, Pirson PA, Pilger D, Halder S, Achuthankutty D, Kashkar H, Ramadan K, Hoppe T. Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun 2016 7 10612  [ PubMed ID = 26842564 ] [ RRC reference ] Chen AT, Guo C, Itani OA, Budaitis BG, Williams TW, Hopkins CE, McEachin RC, Pande M, Grant AR, Yoshina S, Mitani S, Hu PJ. Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans. Genetics 2015 201(2) 613-29  [ PubMed ID = 26219299 ] [ RRC reference ]