Home > 分離済み変異体 > tm6474

分離済み変異体

Allele Name		tm6474
Balance		Not Required
OutCross		Not Accepted
Sequence Name		ZK593.6
Gene Name		lgg-2
Worm Base	Allele Name	tm6474
	Gene Name	lgg-2
	Sequence	ZK593.6
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		25156/25157-25503/25504 (347 bp deletion)
Chromosome		IV
Putative gene structure		complement(join(24970..25123, 25175..25343, 25962..26031))
Map position		4.75
Balancer
Map position of balancer
Sequence of primers		IntRev:CCCGTCCATTGTAAAAGGTC,ExtRev:AGAAGGCCATTCCGTAAGTT,IntFwd:GCGAGGGGCGAAATTAGCAA,ExtFwd:CGGGCTGGAAAATGCGGAGA
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Zhang Q, Li Y, Jian Y, Li M, Wang X. Lysosomal chloride transporter CLH-6 protects lysosome membrane integrity via cathepsin activation. J Cell Biol 2023 222(6)   [ PubMed ID = 37058288 ] [ RRC reference ] Peña-Ramos O, Chiao L, Liu X, Yu X, Yao T, He H, Zhou Z. Autophagosomes fuse to phagosomes and facilitate the degradation of apoptotic cells in Caenorhabditis elegans. Elife 2022 11   [ PubMed ID = 34982028 ] [ RRC reference ] Wu F, Watanabe Y, Guo XY, Qi X, Wang P, Zhao HY, Wang Z, Fujioka Y, Zhang H, Ren JQ, Fang TC, Shen YX, Feng W, Hu JJ, Noda NN, Zhang H. Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy. Mol Cell 2015 60(6) 914-29  [ PubMed ID = 26687600 ] [ RRC reference ] Djeddi A, Al Rawi S, Deuve JL, Perrois C, Liu YY, Russeau M, Sachse M, Galy V. Sperm-inherited organelle clearance in C. elegans relies on LC3-dependent autophagosome targeting to the pericentrosomal area. Development 2015 142(9) 1705-16  [ PubMed ID = 25922527 ] [ RRC reference ]