Home > 分離済み変異体 > tm5915

分離済み変異体

Allele Name		tm5915
Balance		Not Required
OutCross		Not Accepted
Sequence Name		F53B1.6
Gene Name		swip-10
Worm Base	Allele Name	tm5915
	Gene Name	swip-10
	Sequence	F53B1.6
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		14615/14616-TC-14954/14955 (339 bp deletion + 2 bp insertion)
Chromosome		X
Putative gene structure		complement(join(11558..11739, 11784..11901, 11952..12115, 12165..12300, 12351..12481, 14317..14410, 14454..14630, 14675..14874, 14922..14985))
Map position		-17.04
Balancer
Map position of balancer
Sequence of primers		ExtFwd:CTAGTGCATAATGGTAGCAC,IntFwd:GGTAGCACTGAATCATGACT,ExtRev:AAGTATTCTTCACCGGCCAG,IntRev:CGGCCAGTTTGTGTGTATGT
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Rodriguez P, Kalia V, Fenollar-Ferrer C, Gibson CL, Gichi Z, Rajoo A, Matier CD, Pezacki AT, Xiao T, Carvelli L, Chang CJ, Miller GW, Khamoui AV, Boerner J, Blakely RD. Glial swip-10 controls systemic mitochondrial function, oxidative stress, and neuronal viability via copper ion homeostasis. Proc Natl Acad Sci U S A 2024 121(39) e2320611121  [ PubMed ID = 39288174 ] [ RRC reference ] Refai O, Blakely RD. Blockade and reversal of swimming-induced paralysis in C. elegans by the antipsychotic and D2-type dopamine receptor antagonist azaperone. Neurochem Int 2019 123 59-68  [ PubMed ID = 29800604 ] [ RRC reference ] Gibson CL, Balbona JT, Niedzwiecki A, Rodriguez P, Nguyen KCQ, Hall DH, Blakely RD. Glial loss of the metallo β-lactamase domain containing protein, SWIP-10, induces age- and glutamate-signaling dependent, dopamine neuron degeneration. PLoS Genet 2018 14(3) e1007269  [ PubMed ID = 29590100 ] [ RRC reference ] Hardaway JA, Sturgeon SM, Snarrenberg CL, Li Z, Xu XZ, Bermingham DP, Odiase P, Spencer WC, Miller DM 3rd, Carvelli L, Hardie SL, Blakely RD. Glial Expression of the Caenorhabditis elegans Gene swip-10 Supports Glutamate Dependent Control of Extrasynaptic Dopamine Signaling. J Neurosci 2015 35(25) 9409-23  [ PubMed ID = 26109664 ] [ RRC reference ]