分離済み変異体

tm4993

Allele Name

tm4993

Balance

Not Required

OutCross

Not Accepted

Sequence Name

W02B12.15

Gene Name

cisd-1

Worm Base

Allele Name

tm4993

Gene Name

cisd-1

Sequence

W02B12.15

Phenotype

homozygous viable.

Mutation site

23969/23970-24285/24286 (316 bp deletion)

Chromosome

Putative gene structure

complement(join(23652..24054, 24110..24198))

Map position

3.49

Balancer

Map position of balancer

Sequence of primers

ExtRev:AACGCCACAGCATTGTTCTG,IntRev:AAGGTTACGTATCTGGTCTC,ExtFwd:AAGCGCCGCCGTGAAAGAAT,IntFwd:TCCTAACTCGAGTCGCCGAA

Distributed lab

Depositor

Dr. S. Mitani

References

Please submit your publication

Hsiung KC, Tang HY, Cheng ML, Hung LM, Chin-Ming Tan B, Lo SJ.
Mitochondrial Bioenergetics Deficiency in cisd-1 Mutants is Linked to AMPK-Mediated Lipid Metabolism.
Biomed J 2024 100806
[ PubMed ID = 39521176 ] [ RRC reference ]

Ploumi C, Kyriakakis E, Tavernarakis N.
Coupling of autophagy and the mitochondrial intrinsic apoptosis pathway modulates proteostasis and ageing in Caenorhabditis elegans.
Cell Death Dis 2023 14(2) 110
[ PubMed ID = 36774344 ] [ RRC reference ]

King SD, Gray CF, Song L, Mittler R, Padilla PA.
The mitochondrial localized CISD-3.1/CISD-3.2 proteins are required to maintain normal germline structure and function in Caenorhabditis elegans.
PLoS One 2021 16(2) e0245174
[ PubMed ID = 33544710 ] [ RRC reference ]

Hsiung KC, Liu KY, Tsai TF, Yoshina S, Mitani S, Chin-Ming Tan B, Lo SJ.
Defects in CISD-1, a mitochondrial iron-sulfur protein, lower glucose level and ATP production in Caenorhabditis elegans.
Biomed J 2020 43(1) 32-43
[ PubMed ID = 32200954 ] [ RRC reference ]

King SD, Gray CF, Song L, Nechushtai R, Gumienny TL, Mittler R, Padilla PA.
The cisd gene family regulates physiological germline apoptosis through ced-13 and the canonical cell death pathway in Caenorhabditis elegans.
Cell Death Differ 2019 26(1) 162-178
[ PubMed ID = 29666474 ] [ RRC reference ]