分離済み変異体

tm4910

Allele Name

tm4910

Balance

Not Required

OutCross

Not Accepted

Sequence Name

D1044.8

Gene Name

nekl-4

Worm Base

Allele Name

tm4910

Gene Name

nekl-4

Sequence

D1044.8

Phenotype

homozygous viable.

Mutation site

8685/8686-TCA-9205/9206 (520 bp deletion + 3 bp insertion)

Chromosome

III

Putative gene structure

complement(join(6677..6759, 6805..7311, 7526..7930, 8077..8308, 8450..8887, 9003..9597, 9971..10017, 10064..10188, 10235..10494, 10653..10736, 10976..11079))

Map position

-1.58

Balancer

Map position of balancer

Sequence of primers

IntFwd:TTGGGCACATGAGCCCCACA,ExtFwd:CAACGCTACCAATACACTAG,IntRev:GCATACCGAACAACTAGCCA,ExtRev:TAACAAGTGACCGGCACCTC

Distributed lab

Depositor

Dr. S. Mitani/NBRP

References

Please submit your publication

Turan MG, Kantarci H, Cevik S, Kaplan OI.
ARL13B regulates juxtaposed cilia-cilia elongation in BBSome dependent manner in Caenorhabditis elegans.
iScience 2025 28(2) 111791
[ PubMed ID = 39925426 ] [ RRC reference ]

Power KM, Nguyen KC, Silva A, Singh S, Hall DH, Rongo C, Barr MM.
NEKL-4 regulates microtubule stability and mitochondrial health in C. elegans ciliated neurons.
bioRxiv 2024
[ PubMed ID = 38405845 ] [ RRC reference ]

Power KM, Barr MM.
osm-5p- driven fluorophores are differentially expressed in ccpp-1Δ and nekl-4Δ mutant ciliated neurons.
MicroPubl Biol 2024 2024
[ PubMed ID = 39135985 ] [ RRC reference ]

Park K, Li C, Tsiropoulou S, Gonçalves J, Kondratev C, Pelletier L, Blacque OE, Leroux MR.
CDKL kinase regulates the length of the ciliary proximal segment.
Curr Biol 2021 31(11) 2359-2373.e7
[ PubMed ID = 33857430 ] [ RRC reference ]

Power KM, Akella JS, Gu A, Walsh JD, Bellotti S, Morash M, Zhang W, Ramadan YH, Ross N, Golden A, Smith HE, Barr MM, O'Hagan R.
Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function.
PLoS Genet 2020 16(10) e1009052
[ PubMed ID = 33064774 ] [ RRC reference ]