Home > 分離済み変異体 > tm488

分離済み変異体

Allele Name		tm488
Balance		Not Required
OutCross		Not Accepted
Sequence Name		C33B4.3
Gene Name		shn-1
Worm Base	Allele Name	tm488
	Gene Name	shn-1
	Sequence	C33B4.3
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable, Dr. C. Rongo: normal GLR-1::GFP expression.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		23167/23168-24704/24705 (1537 bp deletion)
Chromosome		II
Putative gene structure		complement(join(19454..19683, 20307..20460, 20598..20745, 21230..22071, 22309..22631, 23139..23411, 23469..23810, 23857..24445, 24516..24617, 24877..25146, 25254..25313))
Map position		3.46
Balancer
Map position of balancer
Sequence of primers		ExtFwd:ATCCGATAAACACTGGACGC,ExtRev:CGACGCTATTGTATTTGGCA,IntFwd:ACACTACTTACCACTGCCAC,IntRev:CGCCCTAGCTCGAACTTTTA
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Zoga K, Villiere S, Tikiyani V, Edwards-Cintron AF, Thokachichu P, Nicodemus P, Camara PG, Hart MP. Multiple autism genes influence GABA neuron remodeling via distinct developmental trajectories. Genetics 2025 231(2)   [ PubMed ID = 40795403 ] [ RRC reference ] Gao L, Zhao J, Ardiel E, Hall Q, Nurrish S, Kaplan JM. Shank promotes action potential repolarization by recruiting BK channels to calcium microdomains. Elife 2022 11   [ PubMed ID = 35266450 ] [ RRC reference ] Pym E, Sasidharan N, Thompson-Peer KL, Simon DJ, Anselmo A, Sadreyev R, Hall Q, Nurrish S, Kaplan JM. Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression. Elife 2017 6   [ PubMed ID = 28477407 ] [ RRC reference ] Oh WC, Song HO, Cho JH, Park BJ. ANK repeat-domain of SHN-1 Is indispensable for in vivo SHN-1 function in C. elegans. Mol Cells 2011 31(1) 79-84  [ PubMed ID = 21191812 ] [ RRC reference ]