分離済み変異体

tm465

Allele Nametm465
BalanceNot Required
OutCrossNot Accepted
Sequence NameC09H6.1
Gene Namespr-4
Worm BaseAllele Name tm465
Gene Name spr-4
Sequence C09H6.1
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 6842/6843-8272/8273 (1430 bp deletion)
ChromosomeI
Putative gene structurejoin(5931..6251, 6295..7275, 7333..7464, 8101..8357, 8460..9826, 9922..10583, 11058..11267)
Map position2.53
Balancer
Map position of balancer
Sequence of primersIntFwd:TACGGCGCTCGAAACGAAAG,ExtRev:ACCAGAGTTGGATGGACTTG,ExtFwd:TTCAATCGAGTCGGACAATC,IntRev:TTGGAGAGAGACGATTCTTC
Distributed lab
DepositorDr. S. Mitani
References Please submit your publication
Mazzetto M, Gonzalez LE, Sanchez N, Reinke V.
Characterization of the distribution and dynamics of chromatin states in the C. elegans germline reveals substantial H3K4me3 remodeling during oogenesis.
Genome Res 2024 34(1) 57-69 
[ PubMed ID = 38164610 ] [ RRC reference ]

Zullo JM, Drake D, Aron L, O'Hern P, Dhamne SC, Davidsohn N, Mao CA, Klein WH, Rotenberg A, Bennett DA, Church GM, Colaiácovo MP, Yankner BA.
Regulation of lifespan by neural excitation and REST.
Nature 2019 574(7778) 359-364 
[ PubMed ID = 31619788 ] [ RRC reference ]

Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS, Bennett DA, Colaiácovo MP, Yankner BA.
REST and stress resistance in ageing and Alzheimer's disease.
Nature 2014 507(7493) 448-54 
[ PubMed ID = 24670762 ] [ RRC reference ]