Home > 分離済み変異体 > tm4467

分離済み変異体

Allele Name		tm4467
Balance		Not Required
OutCross		Not Accepted
Sequence Name		ZK75.2
Gene Name		ins-2
Worm Base	Allele Name	tm4467
	Gene Name	ins-2
	Sequence	ZK75.2
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		9866/9867-10246/10247 (380 bp deletion)
Chromosome		II
Putative gene structure		join(9642..9867, 10192..10286)
Map position		-0.75
Balancer
Map position of balancer
Sequence of primers		IntFwd:TATCTCCTGCTATCCACCTG,ExtRev:AGCAGGGTGAGCCACTACAA,IntRev:GTACAATTTAACGGGGCTAG,ExtFwd:CGAGTAAGCCACCTGAAGAG
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Wu T, Duan F, Yang W, Liu H, Caballero A, Fernandes de Abreu DA, Dar AR, Alcedo J, Ch'ng Q, Butcher RA, Zhang Y. Pheromones Modulate Learning by Regulating the Balanced Signals of Two Insulin-like Peptides. Neuron 2019 104(6) 1095-1109.e5  [ PubMed ID = 31676170 ] [ RRC reference ] Lee D, Lee H, Kim N, Lim DS, Lee J. Regulation of a hitchhiking behavior by neuronal insulin and TGF-β signaling in the nematode Caenorhabditis elegans. Biochem Biophys Res Commun 2017 484(2) 323-330  [ PubMed ID = 28131836 ] [ RRC reference ] Burton NO, Furuta T, Webster AK, Kaplan RE, Baugh LR, Arur S, Horvitz HR. Insulin-like signalling to the maternal germline controls progeny response to osmotic stress. Nat Cell Biol 2017 19(3) 252-257  [ PubMed ID = 28166192 ] [ RRC reference ] Hung WL, Wang Y, Chitturi J, Zhen M. A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication. Development 2014 141(8) 1767-79  [ PubMed ID = 24671950 ] [ RRC reference ] Fernandes de Abreu DA, Caballero A, Fardel P, Stroustrup N, Chen Z, Lee K, Keyes WD, Nash ZM, López-Moyado IF, Vaggi F, Cornils A, Regenass M, Neagu A, Ostojic I, Liu C, Cho Y, Sifoglu D, Shen Y, Fontana W, Lu H, Csikasz-Nagy A, Murphy CT, Antebi A, Blanc E, Apfeld J, Zhang Y, Alcedo J, Ch'ng Q. An insulin-to-insulin regulatory network orchestrates phenotypic specificity in development and physiology. PLoS Genet 2014 10(3) e1004225  [ PubMed ID = 24675767 ] [ RRC reference ] Hung WL, Hwang C, Gao S, Liao EH, Chitturi J, Wang Y, Li H, Stigloher C, Bessereau JL, Zhen M. Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development. EMBO J 2013 32(12) 1745-60  [ PubMed ID = 23665919 ] [ RRC reference ]