Home > 分離済み変異体 > tm4397

分離済み変異体

Allele Name		tm4397
Allele Type		通常株
Sequence Name		T04C10.4
Gene Name		atf-5
Worm Base	Allele Name	tm4397
	Gene Name	atf-5
	Sequence	T04C10.4
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		959/960-1765/1766 (806 bp deletion)
Chromosome		X
Putative gene structure		complement(join(450..527, 572..847, 1372..1644))
Map position		21.36
Balancer
Map position of balancer
Sequence of primers		ExtFwd:CGCTCCAACTCGGATACCTG,IntFwd:GATCCTTCAGCTTGCCATTG,ExtRev:GTCATCGCGAACGCTCCTTC,IntRev:GCCACAGCGCCAATTTGTAC
Distributed lab
Depositor		Dr. S. Mitani
References		Please submit your publication Kawano T, Kashiwagi M, Kanuka M, Chen CK, Yasugaki S, Hatori S, Miyazaki S, Tanaka K, Fujita H, Nakajima T, Yanagisawa M, Nakagawa Y, Hayashi Y. ER proteostasis regulators cell-non-autonomously control sleep. Cell Rep 2023 42(3) 112267  [ PubMed ID = 36924492 ] [ RRC reference ] Statzer C, Meng J, Venz R, Bland M, Robida-Stubbs S, Patel K, Petrovic D, Emsley R, Liu P, Morantte I, Haynes C, Mair WB, Longchamp A, Filipovic MR, Blackwell TK, Ewald CY. ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1. Nat Commun 2022 13(1) 967  [ PubMed ID = 35181679 ] [ RRC reference ] Ferraz RC, Camara H, De-Souza EA, Pinto S, Pinca AP, Silva RC, Sato VN, Castilho BA, Mori MA. IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans. BMC Biol 2016 14(1) 87  [ PubMed ID = 27717342 ] [ RRC reference ] Hernández IH, Torres-Peraza J, Santos-Galindo M, Ramos-Morón E, Fernández-Fernández MR, Pérez-Álvarez MJ, Miranda-Vizuete A, Lucas JJ. The neuroprotective transcription factor ATF5 is decreased and sequestered into polyglutamine inclusions in Huntington's disease. Acta Neuropathol 2017 134(6) 839-850  [ PubMed ID = 28861715 ] [ RRC reference ] Glover-Cutter KM, Lin S, Blackwell TK. Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf. PLoS Genet 2013 9(9) e1003701  [ PubMed ID = 24068940 ] [ RRC reference ]