分離済み変異体

tm4387

Allele Nametm4387
BalanceNot Required
OutCrossNot Accepted
Sequence NameH12D21.7
Gene NameH12D21.7
Worm BaseAllele Name tm4387
Gene Name H12D21.7
Sequence H12D21.7
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 16179/16180-16734/16735 (555 bp deletion)
ChromosomeV
Putative gene structurejoin(16081..16206, 16366..16624, 16733..16950, 17007..17069)
Map position6.98
Balancer
Map position of balancer
Sequence of primersIntRev:AGTAGCTCCAAAATCGGGTC,ExtFwd:GGCAGCAGTTATAATGAGAG,ExtRev:GGGGGTTCCAACTATGCTTA,IntFwd:TAGTAAGTGCACGCATGGAG
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Petrovic D, Slade L, Paikopoulos Y, D'Andrea D, Savic N, Stancic A, Miljkovic JL, Vignane T, Drekolia MK, Mladenovic D, Sutulovic N, Refeyton A, Kolakovic M, Jovanovic VM, Zivanovic J, Miler M, Vellecco V, Brancaleone V, Bucci M, Casey AM, Yu C, Kasarla SS, Smith KW, Kalfe-Yildiz A, Stenzel M, Miranda-Vizuete A, Hergenröder R, Phapale P, Stanojlovic O, Ivanovic-Burmazovic I, Vlaski-Lafarge M, Bibli SI, Murphy MP, Otasevic V, Filipovic MR.
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation.
Cell Metab 2025 37(2) 542-556.e14 
[ PubMed ID = 39842434 ] [ RRC reference ]