Home > 分離済み変異体 > tm4374

分離済み変異体

Allele Name		tm4374
Balance		Not Required
OutCross		Not Accepted
Sequence Name		R09B3.1
Gene Name		exo-3
Worm Base	Allele Name	tm4374
	Gene Name	exo-3
	Sequence	R09B3.1
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		2059/2060-2519/2520 (460 bp deletion)
Chromosome		I
Putative gene structure		complement(join(1650..1724, 2032..2247, 2308..2634, 2964..3212))
Map position		12.91
Balancer
Map position of balancer
Sequence of primers		IntRev:TCATCCTTCCATCCGCCGAC,ExtFwd:TCCACCGGGATTTTACGGGA,IntFwd:GCTTCCAGACGAGACCTTAT,ExtRev:CGCGTCAACCTCGCCAACAA
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Yan J, Bhanshali F, Shuzenji C, Mendenhall TT, Taylor SKB, Ermakova G, Cheng X, Bai P, Diwan G, Seraj D, Meyer JN, Sorensen PH, Hartman JH, Taubert S. Eukaryotic Elongation Factor 2 Kinase EFK-1/eEF2K promotes starvation resistance by preventing oxidative damage in C. elegans. Nat Commun 2025 16(1) 1752  [ PubMed ID = 39966347 ] [ RRC reference ] Nicolai MM, Weishaupt AK, Baesler J, Brinkmann V, Wellenberg A, Winkelbeiner N, Gremme A, Aschner M, Fritz G, Schwerdtle T, Bornhorst J. Effects of Manganese on Genomic Integrity in the Multicellular Model Organism Caenorhabditis elegans. Int J Mol Sci 2021 22(20)   [ PubMed ID = 34681565 ] [ RRC reference ] Miyaji M, Hayashi Y, Funakoshi M, Tanaka A, Zhang-Akiyama QM. AP endonuclease EXO-3 deficiency causes developmental delay and abnormal vulval organogenesis, Pvl, through DNA glycosylase-initiated checkpoint activation in Caenorhabditis elegans. Sci Rep 2018 8(1) 16736  [ PubMed ID = 30425296 ] [ RRC reference ] Papaluca A, Wagner JR, Saragovi HU, Ramotar D. UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans. Sci Rep 2018 8(1) 6860  [ PubMed ID = 29717169 ] [ RRC reference ] Kato Y, Miyaji M, Zhang-Akiyama QM. FUdR extends the lifespan of the short-lived AP endonuclease mutant in Caenorhabditis elegans in a fertility-dependent manner. Genes Genet Syst 2017 91(4) 201-207  [ PubMed ID = 27582048 ] [ RRC reference ] Kato Y, Moriwaki T, Funakoshi M, Zhang-Akiyama QM. Caenorhabditis elegans EXO-3 contributes to longevity and reproduction: differential roles in somatic cells and germ cells. Mutat Res 2015 772 46-54  [ PubMed ID = 25772110 ] [ RRC reference ] SenGupta T, Torgersen ML, Kassahun H, Vellai T, Simonsen A, Nilsen H. Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy. Nat Commun 2013 4 2674  [ PubMed ID = 24154628 ] [ RRC reference ]