Home > 分離済み変異体 > tm4344

分離済み変異体

Allele Name		tm4344
Balance		Not Required
OutCross		Not Accepted
Sequence Name		K10D2.2
Gene Name		pup-2
Worm Base	Allele Name	tm4344
	Gene Name	pup-2
	Sequence	K10D2.2
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		19350/19351-TT-19931/19932 (581 bp deletion + 2 bp insertion)
Chromosome		III
Putative gene structure		join(18888..18902, 18950..19187, 19263..19329, 19380..19793, 19855..20369, 20418..20575, 20638..20757)
Map position		-2.03
Balancer
Map position of balancer
Sequence of primers		IntFwd:CTGACCACAAGATCCCTCAC,ExtRev:GAAAGAAACTCCGAGCGCAT,ExtFwd:TCACTGGACACCACTGACCA,IntRev:CTTGGCATATCAACACCTTG
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Kelley LH, Caldas IV, Sullenberger MT, Yongblah KE, Niazi AM, Iyer A, Li Y, Tran PM, Valen E, Ahmed-Braimah YH, Maine EM. Poly(U) polymerase activity in Caenorhabditis elegans regulates abundance and tailing of sRNA and mRNA. Genetics 2024 228(2)   [ PubMed ID = 39067069 ] [ RRC reference ] Vieux KF, Prothro KP, Kelley LH, Palmer C, Maine EM, Veksler-Lublinsky I, McJunkin K. Screening by deep sequencing reveals mediators of microRNA tailing in C. elegans. Nucleic Acids Res 2021 49(19) 11167-11180  [ PubMed ID = 34586415 ] [ RRC reference ] Wang Y, Weng C, Chen X, Zhou X, Huang X, Yan Y, Zhu C. CDE-1 suppresses the production of risiRNA by coupling polyuridylation and degradation of rRNA. BMC Biol 2020 18(1) 115  [ PubMed ID = 32887607 ] [ RRC reference ] Li Y, Maine EM. The balance of poly(U) polymerase activity ensures germline identity, survival and development in Caenorhabditis elegans. Development 2018 145(19)   [ PubMed ID = 30305273 ] [ RRC reference ] Weaver BP, Zabinsky R, Weaver YM, Lee ES, Xue D, Han M. CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans. Elife 2014 3 e04265  [ PubMed ID = 25432023 ] [ RRC reference ] Van Wynsberghe PM, Kai ZS, Massirer KB, Burton VH, Yeo GW, Pasquinelli AE. LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans. Nat Struct Mol Biol 2011 18(3) 302-8  [ PubMed ID = 21297634 ] [ RRC reference ]