分離済み変異体

tm432

Allele Nametm432
BalanceNot Required
OutCrossNot Accepted
Sequence NameC17C3.7
Gene Namehlh-25
Worm BaseAllele Name tm432
Gene Name hlh-25
Sequence C17C3.7
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable. Dr. R. Lin: normal cell division during 8-30 cell stage. Dr. P. Sengupta: normal dye-filling into sensory neurons.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 6160/6161-C-7121/7122 (961 bp deletion, 1 bp insertion)
ChromosomeII
Putative gene structurejoin(4597..4731, 5131..5288, 5345..5575, 5623..6040)
Map position-1.19
Balancer
Map position of balancer
Sequence of primersIntFwd:GAACCCAAGCAATGCGAAGG,ExtFwd:TACGCGTGGTTCTCATGGTG,ExtRev:TGCCCAGCGGAATTTGGAGT,IntRev:CACTCGGTTCCTTGAACTTT
Distributed lab
DepositorDr. S. Mitani
References Please submit your publication
Verschuren J, van Schendel R, van Bostelen I, Verkennis AEE, Knipscheer P, Tijsterman M.
FAN1-mediated translesion synthesis and POLQ/HELQ-mediated end joining generate interstrand crosslink-induced mutations.
Nat Commun 2025 16(1) 2495 
[ PubMed ID = 40082407 ] [ RRC reference ]