分離済み変異体

tm4182

Allele Nametm4182
BalanceNot Required
OutCrossNot Accepted
Sequence NameY42A5A.4
Gene NameY42A5A.4
Worm BaseAllele Name tm4182
Gene Name Y42A5A.4
Sequence Y42A5A.4
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 19180/19181-20030/20031 (850 bp deletion)
ChromosomeV
Putative gene structurejoin(18298..18465, 18882..19003, 19046..19209, 19332..19529, 19579..19718, 19760..19888, 19935..20075)
Map position2.95
Balancer
Map position of balancer
Sequence of primersExtFwd:GACATATCACCTGCGCTCAT,IntFwd:CCGTATCTTTACAGCAACTG,ExtRev:TCACTGGGTCTCCCCACGAT,IntRev:CCGGCATATTGATTCATGCT
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Park K, Li C, Tsiropoulou S, Gonçalves J, Kondratev C, Pelletier L, Blacque OE, Leroux MR.
CDKL kinase regulates the length of the ciliary proximal segment.
Curr Biol 2021 31(11) 2359-2373.e7 
[ PubMed ID = 33857430 ] [ RRC reference ]

Canning P, Park K, Gonçalves J, Li C, Howard CJ, Sharpe TD, Holt LJ, Pelletier L, Bullock AN, Leroux MR.
CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.
Cell Rep 2018 22(4) 885-894 
[ PubMed ID = 29420175 ] [ RRC reference ]

Li C, Jensen VL, Park K, Kennedy J, Garcia-Gonzalo FR, Romani M, De Mori R, Bruel AL, Gaillard D, Doray B, Lopez E, Rivière JB, Faivre L, Thauvin-Robinet C, Reiter JF, Blacque OE, Valente EM, Leroux MR.
MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone.
PLoS Biol 2016 14(3) e1002416 
[ PubMed ID = 26982032 ] [ RRC reference ]