分離済み変異体

tm415

Allele Nametm415
BalanceNot Required
OutCrossNot Accepted
Sequence NameC26C6.1
Gene Namepbrm-1
Worm BaseAllele Name tm415
Gene Name pbrm-1
Sequence C26C6.1
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable. Dr. J. Ahringer: low percentage Pvl and Rup adults (might be from side mutation). Dr. H. Sawa: weak Psa, One arm gonad. Dr. W. Vermeulen: partial Lva.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 945/946-CTCTC-1372/1373 (427 bp deletion, 5 bp insertion)
ChromosomeI
Putative gene structurejoin(Z72517:29638..29763, Z72517:29810..30567, 105..344, 397..739, 796..1322, 1401..2346, 2395..3152, 3345..3520, 3570..3670, 3718..3789, 5050..5460, 5558..5771, 5855..6291, 6338..6624, 6677..6800, 6847..6966)
Map position2.1
Balancer
Map position of balancer
Sequence of primersIntFwd:GTTACGCTGGCTGACAACTT,IntRev:AACCACTCAGAACCGCTGAA,ExtFwd:CTGTTCACGAGAAAGATCGA,ExtRev:AGCAAACCAGCAGCCGGAAA
Distributed lab
DepositorDr. S. Mitani
References Please submit your publication
Enríquez P, Krajewski K, Strahl BD, Rothbart SB, Dowen RH, Rose RB.
Binding specificity and function of the SWI/SNF subunit SMARCA4 bromodomain interaction with acetylated histone H3K14.
J Biol Chem 2021 297(4) 101145 
[ PubMed ID = 34473995 ] [ RRC reference ]

Mathies LD, Blackwell GG, Austin MK, Edwards AC, Riley BP, Davies AG, Bettinger JC.
SWI/SNF chromatin remodeling regulates alcohol response behaviors in Caenorhabditis elegans and is associated with alcohol dependence in humans.
Proc Natl Acad Sci U S A 2015 112(10) 3032-7 
[ PubMed ID = 25713357 ] [ RRC reference ]

Large EE, Mathies LD.
Caenorhabditis elegans SWI/SNF subunits control sequential developmental stages in the somatic gonad.
G3 (Bethesda) 2014 4(3) 471-83 
[ PubMed ID = 24402584 ] [ RRC reference ]

Shibata Y, Uchida M, Takeshita H, Nishiwaki K, Sawa H.
Multiple functions of PBRM-1/Polybromo- and LET-526/Osa-containing chromatin remodeling complexes in C. elegans development.
Dev Biol 2012 361(2) 349-57 
[ PubMed ID = 22119053 ] [ RRC reference ]

Lans H, Marteijn JA, Schumacher B, Hoeijmakers JH, Jansen G, Vermeulen W.
Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development.
PLoS Genet 2010 6(5) e1000941 
[ PubMed ID = 20463888 ] [ RRC reference ]