分離済み変異体

tm3715

Allele Nametm3715
Allele Typeバランス済
Sequence NameF28D1.8
Gene NameF28D1.8
Worm BaseAllele Name tm3715
Gene Name F28D1.8
Sequence F28D1.8
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" lethal or sterile.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 18207/18208-18625/18626 (418 bp deletion)
ChromosomeIV
Putative gene structurecomplement(join(17675..18113, 18285..18442, 18494..18670, 19174..19271, 19315..19525))
Map position5.9
BalancernT1
Map position of balancer
Sequence of primersIntRev:CAAGGCGCACACTCTCTTTC,IntFwd:ACTCGAACCAATTGGCAGGT,ExtRev:ACGATCGAAGTTGGCTGCGA,ExtFwd:GACCAAGTACCGTATTCCTG
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Takayama J, Tajima T, Onami S, Nishimura H.
C. elegans spermatozoa lacking spe-45 are incapable of fusing with the oocyte plasma membrane.
MicroPubl Biol 2021 2021  
[ PubMed ID = 33644705 ] [ RRC reference ]

Nishimura H, Tajima T, Comstra HS, Gleason EJ, L'Hernault SW.
The Immunoglobulin-like Gene spe-45 Acts during Fertilization in Caenorhabditis elegans like the Mouse Izumo1 Gene.
Curr Biol 2015 25(24) 3225-31 
[ PubMed ID = 26671669 ] [ RRC reference ]

Singaravelu G, Rahimi S, Krauchunas A, Rizvi A, Dharia S, Shakes D, Smith H, Golden A, Singson A.
Forward Genetics Identifies a Requirement for the Izumo-like Immunoglobulin Superfamily spe-45 Gene in Caenorhabditis elegans Fertilization.
Curr Biol 2015 25(24) 3220-4 
[ PubMed ID = 26671668 ] [ RRC reference ]

Nishimura H, L'Hernault SW.
Gamete interactions require transmembranous immunoglobulin-like proteins with conserved roles during evolution.
Worm 2016 5(3) e1197485 
[ PubMed ID = 27695654 ] [ RRC reference ]