分離済み変異体

tm3715

Allele Nametm3715
Allele Typeバランス済
Sequence NameF28D1.8
Gene NameF28D1.8
Worm BaseAllele Name tm3715
Gene Name F28D1.8
Sequence F28D1.8
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" lethal or sterile.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 18207/18208-18625/18626 (418 bp deletion)
ChromosomeIV
Putative gene structurecomplement(join(17675..18113, 18285..18442, 18494..18670, 19174..19271, 19315..19525))
Map position5.9
BalancernT1
Map position of balancer
Sequence of primersIntRev:CAAGGCGCACACTCTCTTTC,IntFwd:ACTCGAACCAATTGGCAGGT,ExtRev:ACGATCGAAGTTGGCTGCGA,ExtFwd:GACCAAGTACCGTATTCCTG
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Wang G, Guasp RJ, Salam S, Chuang E, Morera A, Smart AJ, Jimenez D, Shekhar S, Friedman E, Melentijevic I, Nguyen KC, Hall DH, Grant BD, Driscoll M.
Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons.
Elife 2024 13  
[ PubMed ID = 39255003 ] [ RRC reference ]

Takayama J, Tajima T, Onami S, Nishimura H.
C. elegans spermatozoa lacking spe-45 are incapable of fusing with the oocyte plasma membrane.
MicroPubl Biol 2021 2021  
[ PubMed ID = 33644705 ] [ RRC reference ]

Nishimura H, Tajima T, Comstra HS, Gleason EJ, L'Hernault SW.
The Immunoglobulin-like Gene spe-45 Acts during Fertilization in Caenorhabditis elegans like the Mouse Izumo1 Gene.
Curr Biol 2015 25(24) 3225-31 
[ PubMed ID = 26671669 ] [ RRC reference ]

Singaravelu G, Rahimi S, Krauchunas A, Rizvi A, Dharia S, Shakes D, Smith H, Golden A, Singson A.
Forward Genetics Identifies a Requirement for the Izumo-like Immunoglobulin Superfamily spe-45 Gene in Caenorhabditis elegans Fertilization.
Curr Biol 2015 25(24) 3220-4 
[ PubMed ID = 26671668 ] [ RRC reference ]

Nishimura H, L'Hernault SW.
Gamete interactions require transmembranous immunoglobulin-like proteins with conserved roles during evolution.
Worm 2016 5(3) e1197485 
[ PubMed ID = 27695654 ] [ RRC reference ]