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分離済み変異体

Allele Name		tm3468
Allele Type		通常株
Sequence Name		F42H11.2
Gene Name		lem-3
Worm Base	Allele Name	tm3468
	Gene Name	lem-3
	Sequence	F42H11.2
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr.M. Hengartner: increased embryonic lethality after X-irradiation.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		3525/3526-[K07A1]238/239 (330 bp deletion)
Chromosome		I
Putative gene structure		complement(join(1751..1880, 1931..2007, 2053..2138, 2187..2556, 2620..2703, 2747..3722, Z81097.1:106..252, Z81097.1:306..480, Z81097.1:531..684))
Map position		3.81
Balancer
Map position of balancer
Sequence of primers		IntFwd:CCGGTGAATATCCACGGTTC,ExtFwd:CAACGTCAGCATCCGGTGAA,ExtRev:TGCCGCCATCTGTCTGTCTG,IntRev:CATCTCCGCAGTGAAACTTA
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Hong Y, Sonneville R, Wang B, Scheidt V, Meier B, Woglar A, Demetriou S, Labib K, Jantsch V, Gartner A. LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis. Nat Commun 2018 9(1) 728  [ PubMed ID = 29463814 ] [ RRC reference ] Hong Y, Velkova M, Silva N, Jagut M, Scheidt V, Labib K, Jantsch V, Gartner A. The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans. PLoS Genet 2018 14(6) e1007453  [ PubMed ID = 29879106 ] [ RRC reference ] Dittrich CM, Kratz K, Sendoel A, Gruenbaum Y, Jiricny J, Hengartner MO. LEM-3 - A LEM domain containing nuclease involved in the DNA damage response in C. elegans. PLoS One 2012 7(2) e24555  [ PubMed ID = 22383942 ] [ RRC reference ]