Home > 分離済み変異体 > tm3468

分離済み変異体

Allele Name		tm3468
Balance		Not Required
OutCross		Not Accepted
Sequence Name		F42H11.2
Gene Name		lem-3
Worm Base	Allele Name	tm3468
	Gene Name	lem-3
	Sequence	F42H11.2
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr.M. Hengartner: increased embryonic lethality after X-irradiation.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		3525/3526-[K07A1]238/239 (330 bp deletion)
Chromosome		I
Putative gene structure		complement(join(1751..1880, 1931..2007, 2053..2138, 2187..2556, 2620..2703, 2747..3722, Z81097.1:106..252, Z81097.1:306..480, Z81097.1:531..684))
Map position		3.81
Balancer
Map position of balancer
Sequence of primers		IntFwd:CCGGTGAATATCCACGGTTC,ExtFwd:CAACGTCAGCATCCGGTGAA,ExtRev:TGCCGCCATCTGTCTGTCTG,IntRev:CATCTCCGCAGTGAAACTTA
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Mazzetto M, Gonzalez LE, Sanchez N, Reinke V. Characterization of the distribution and dynamics of chromatin states in the C. elegans germline reveals substantial H3K4me3 remodeling during oogenesis. Genome Res 2024 34(1) 57-69  [ PubMed ID = 38164610 ] [ RRC reference ] Barger SR, Penfield L, Bahmanyar S. Nuclear envelope assembly relies on CHMP-7 in the absence of BAF-LEM-mediated hole closure. J Cell Sci 2023 136(21)   [ PubMed ID = 37795681 ] [ RRC reference ] Hong Y, Velkova M, Silva N, Jagut M, Scheidt V, Labib K, Jantsch V, Gartner A. The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans. PLoS Genet 2018 14(6) e1007453  [ PubMed ID = 29879106 ] [ RRC reference ] Hong Y, Sonneville R, Wang B, Scheidt V, Meier B, Woglar A, Demetriou S, Labib K, Jantsch V, Gartner A. LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis. Nat Commun 2018 9(1) 728  [ PubMed ID = 29463814 ] [ RRC reference ] Dittrich CM, Kratz K, Sendoel A, Gruenbaum Y, Jiricny J, Hengartner MO. LEM-3 - A LEM domain containing nuclease involved in the DNA damage response in C. elegans. PLoS One 2012 7(2) e24555  [ PubMed ID = 22383942 ] [ RRC reference ]