分離済み変異体

tm3433

Allele Name

tm3433

Balance

Not Required

OutCross

Not Accepted

Sequence Name

C27A7.4

Gene Name

che-11

Worm Base

Allele Name

tm3433

Gene Name

che-11

Sequence

C27A7.4

Phenotype

homozygous viable.

Mutation site

19399/19400-19939/19940 (540 bp deletion)

Chromosome

Putative gene structure

complement(join(17635..17972, 18027..18189, 18234..18446, 18489..18610, 18658..19472, 19520..19900, 19948..20056, 20103..20316, 20425..20706, 20752..20869, 20919..21184, 21231..21496, 22134..22455, 23059..23251, 23301..23422, 23470..23555, 23607..23679))

Map position

3.67

Balancer

Map position of balancer

Sequence of primers

ExtFwd:CCAGGAAGATCTTCGTAGTA,IntFwd:CCACCCGCCATCAAGCATAA,ExtRev:GGTAGTCACTTATGACGTAC,IntRev:TGGATGGCAGTTGCTACTAC

Distributed lab

Depositor

Dr. S. Mitani/NBRP

References

Please submit your publication

Turan MG, Kantarci H, Cevik S, Kaplan OI.
ARL13B regulates juxtaposed cilia-cilia elongation in BBSome dependent manner in Caenorhabditis elegans.
iScience 2025 28(2) 111791
[ PubMed ID = 39925426 ] [ RRC reference ]

Cevik S, Peng X, Beyer T, Pir MS, Yenisert F, Woerz F, Hoffmann F, Altunkaynak B, Pir B, Boldt K, Karaman A, Cakiroglu M, Oner SS, Cao Y, Ueffing M, Kaplan OI.
WDR31 displays functional redundancy with GTPase-activating proteins (GAPs) ELMOD and RP2 in regulating IFT complex and recruiting the BBSome to cilium.
Life Sci Alliance 2023 6(8)
[ PubMed ID = 37208194 ] [ RRC reference ]

Reed R, Park K, Waddell B, Timbers TA, Li C, Baxi K, Giacomin RM, Leroux MR, Carvalho CE.
The Caenorhabditis elegans Shugoshin regulates TAC-1 in cilia.
Sci Rep 2023 13(1) 9410
[ PubMed ID = 37296204 ] [ RRC reference ]

Kaplan OI.
RPI-1 (human DCDC2) displays functional redundancy with Nephronophthisis 4 in regulating cilia biogenesis in C. elegans.
Turk J Biol 2023 47(1) 74-83
[ PubMed ID = 37529113 ] [ RRC reference ]

Park K, Li C, Tsiropoulou S, Gonçalves J, Kondratev C, Pelletier L, Blacque OE, Leroux MR.
CDKL kinase regulates the length of the ciliary proximal segment.
Curr Biol 2021 31(11) 2359-2373.e7
[ PubMed ID = 33857430 ] [ RRC reference ]

Cevik S, Kaplan OI.
Subcellular localization of the voltage-gated K+ channel EGL-36 , a member of the KV3 subfamily, in the ciliated sensory neurons in C. elegans.
MicroPubl Biol 2021 2021
[ PubMed ID = 33688626 ] [ RRC reference ]

Serwas D, Su TY, Roessler M, Wang S, Dammermann A.
Centrioles initiate cilia assembly but are dispensable for maturation and maintenance in C. elegans.
J Cell Biol 2017 216(6) 1659-1671
[ PubMed ID = 28411189 ] [ RRC reference ]

Prevo B, Mangeol P, Oswald F, Scholey JM, Peterman EJ.
Functional differentiation of cooperating kinesin-2 motors orchestrates cargo import and transport in C. elegans cilia.
Nat Cell Biol 2015 17(12) 1536-45
[ PubMed ID = 26523365 ] [ RRC reference ]