分離済み変異体

tm3378

Allele Nametm3378
BalanceNot Required
OutCrossNot Accepted
Sequence NameF02H6.5
Gene NameF02H6.5
Worm BaseAllele Name tm3378
Gene Name F02H6.5
Sequence F02H6.5
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 24349/24350-24794/24795 (445 bp deletion)
ChromosomeIV
Putative gene structurejoin(23025..23049, 23971..24308, 24582..24680, 25326..25619, 25786..25956, 26121..26228, 26539..26682, 27113..27349)
Map position11.6
Balancer
Map position of balancer
Sequence of primersIntRev:CCGCGGATTTCTAGATATAG,ExtRev:ACAGTGCATTTCCACCCTGA,IntFwd:CCATGATGGAAGCCCGGAAT,ExtFwd:CGGAGAGAGCGATAGAATCT
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Romanelli-Cedrez L, Vairoletti F, Salinas G.
Rhodoquinone-dependent electron transport chain is essential for Caenorhabditis elegans survival in hydrogen sulfide environments.
J Biol Chem 2024 300(9) 107708 
[ PubMed ID = 39178951 ] [ RRC reference ]

Feng D, Qu L, Powell-Coffman JA.
Whole genome profiling of short-term hypoxia induced genes and identification of HIF-1 binding sites provide insights into HIF-1 function in Caenorhabditis elegans.
PLoS One 2024 19(5) e0295094 
[ PubMed ID = 38743782 ] [ RRC reference ]

Romanelli-Credrez L, Doitsidou M, Alkema MJ, Salinas G.
HIF-1 Has a Central Role in Caenorhabditis elegans Organismal Response to Selenium.
Front Genet 2020 11 63 
[ PubMed ID = 32161616 ] [ RRC reference ]

Horsman JW, Heinis FI, Miller DL.
A Novel Mechanism To Prevent H2S Toxicity in Caenorhabditis elegans.
Genetics 2019 213(2) 481-490 
[ PubMed ID = 31371406 ] [ RRC reference ]

Horsman JW, Miller DL.
Mitochondrial Sulfide Quinone Oxidoreductase Prevents Activation of the Unfolded Protein Response in Hydrogen Sulfide.
J Biol Chem 2016 291(10) 5320-5 
[ PubMed ID = 26677221 ] [ RRC reference ]

Budde MW, Roth MB.
The response of Caenorhabditis elegans to hydrogen sulfide and hydrogen cyanide.
Genetics 2011 189(2) 521-32 
[ PubMed ID = 21840852 ] [ RRC reference ]