分離済み変異体

tm331

Allele Name

tm331

Balance

Not Required

OutCross

Not Accepted

Sequence Name

VZK822L.1

Gene Name

fat-6

Worm Base

Allele Name

tm331

Gene Name

fat-6

Sequence

VZK822L.1

Phenotype

homozygous viable. Dr. H. Arai: WT (Brood size, embryonic lethality, larval lehtality, growth rate), Dr. G. Hermann: wild-type gut granules. Dr. K. Sakamoto: J. Biochem 144, 149 (2008). Dr. J. Watts & Dr. J. Browse: PLoS Genetics 2, e108 (2006), Genetics 176, 865 (2007).

Mutation site

6436/6437-AATACCGCAATAGGGTTCACTTAAAAACGAATGTTGTAGAATGAAAAAAGAAATAGAAAAGAAGATAAGTGATGTTGAGCATAAAACATAAGATGTGTTGAAAAAGAAAGAAAAACGGAAAATTTGATCAAATTTGAAACGTATCTTTTCCTCTTCTCCCTTTCTTCTTACTTCCGTTCTTCTCTTACTTTCAATCCAATCATGCTCCTTGTCTTCTCATAATTTTATTGCTTTTTGTCTCCTCTTTTCTCGCCTTCTGCAACACAAAGTGCAAACCTAAATTCCATTTAGTTTTCTTACACAAAATGATTGAAAAGTAAATGTTTTATGATGAAAAGTATGAGCCATCATTCATCTGATCATCCATCTCTTTTGTTTAAATATCAATTTTTTAGATTGTGAAGACATGTGAGCAACTTGAAACTGAT-7668/7669 (1232 bp deletion + 428 bp insertion)

Chromosome

Putative gene structure

complement(join(5893..6172,6281..6442,6498..6834, 7133..7253,7623..7742)

Map position

5.39

Balancer

Map position of balancer

Sequence of primers

ExtFwd:ACTCTTGGCACAAAACGGCG,IntFwd:GTTCCCAGTTTTTGACGTGT,IntRev:AAAGGGCCTTGCGTAGTGTA,ExtRev:GATATCAGACGACGGGCAGG

Distributed lab

Depositor

Dr. S. Mitani/NBRP

References

Please submit your publication

Jiang WI, Vale GDD, Pearce Q, Kong K, Zhou W, McDonald JG, Cox JE, Singhal NS, Ma DK.
Conserved lipid metabolic reprogramming confers hypoxic and aging resilience.
EMBO Rep 2026 27(3) 704-728
[ PubMed ID = 41381735 ] [ RRC reference ]

Yamamoto KK, Wan M, Penkar RS, Savage-Dunn C.
BMP-dependent mobilization of fatty acid metabolism promotes Caenorhabditis elegans survival on a bacterial pathogen.
Dis Model Mech 2025 18(11)
[ PubMed ID = 41048044 ] [ RRC reference ]

Li KUR, Lo WK, Yang M, Wang C, Lau CY, Lee JC, Zheng C.
Microbacterium diet rich in branched chain fatty acids promotes lipid droplet enlargement and impacts organismal health in C. elegans.
Cell Rep 2025 44(10) 116292
[ PubMed ID = 40960936 ] [ RRC reference ]

An L, Geng B, An L, Wang Y, Zhang Z, Fu X, Chen J, Ma J.
Low molecular weight protein tyrosine phosphatase: A driver of lipid metabolic remodeling in Caenorhabditis elegans.
Int J Biol Macromol 2025 306(Pt 1) 141332
[ PubMed ID = 39988157 ] [ RRC reference ]

Kim AT, Park Y.
Esculetin Inhibits Fat Accumulation Through Insulin/Insulin-like Growth Factor- and AMP-Activated Protein Kinase-Dependent Pathways in Caenorhabditis elegans.
Nutrients 2025 17(9)
[ PubMed ID = 40362874 ] [ RRC reference ]

Li Q, Zhou X, Zhang X, Zhang C, Zhang SO.
Nuclear receptor signaling regulates compartmentalized phosphatidylcholine remodeling to facilitate thermosensitive lipid droplet fusion.
Nat Commun 2025 16(1) 3955
[ PubMed ID = 40289189 ] [ RRC reference ]

Battista B, Hernandez-Cravero B, Colaiácovo MP, Cochella L, Binolfi A, de Mendoza D.
An inducible and reversible system to regulate unsaturated fatty acid biosynthesis in C. elegans.
G3 (Bethesda) 2025 15(4)
[ PubMed ID = 40097139 ] [ RRC reference ]

Yamamoto KK, Wan M, Penkar RS, Savage-Dunn C.
BMP-Dependent Mobilization of Fatty Acid Metabolism Promotes Caenorhabditis elegans Survival on a Bacterial Pathogen.
bioRxiv 2025
[ PubMed ID = 40161651 ] [ RRC reference ]

Zhang L, Yu J, Gao X, Yan Y, Wang X, Shi H, Fang M, Liu Y, Kim YB, Zhu H, Wu X, Huang C, Fan S.
Targeting farnesoid X receptor as aging intervention therapy.
Acta Pharm Sin B 2025 15(3) 1359-1382
[ PubMed ID = 40370561 ] [ RRC reference ]

Tuckowski AM, Beydoun S, Kitto ES, Bhat A, Howington MB, Sridhar A, Bhandari M, Chambers K, Leiser SF.
fmo-4 promotes longevity and stress resistance via ER to mitochondria calcium regulation in C. elegans.
Elife 2025 13
[ PubMed ID = 39951337 ] [ RRC reference ]

Vora M, Dietz J, Wing Z, George K, Kelly Liu J, Rongo C, Savage-Dunn C.
Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion.
Elife 2025 13
[ PubMed ID = 39887187 ] [ RRC reference ]

Vora M, Dietz J, Wing Z, George K, Liu J, Rongo C, Savage-Dunn C.
Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion.
bioRxiv 2025
[ PubMed ID = 38895257 ] [ RRC reference ]

Ruan M, Xu F, Li N, Yu J, Teng F, Tang J, Huang C, Zhu H.
Free long-chain fatty acids trigger early postembryonic development in starved Caenorhabditis elegans by suppressing mTORC1.
PLoS Biol 2024 22(10) e3002841
[ PubMed ID = 39436954 ] [ RRC reference ]

Murari E, Meadows D, Cuda N, Mangone M.
A comprehensive analysis of 3'UTRs in Caenorhabditis elegans.
Nucleic Acids Res 2024 52(13) 7523-7538
[ PubMed ID = 38917330 ] [ RRC reference ]

Weng Y, Murphy CT.
Male-specific behavioral and transcriptomic changes in aging C. elegans neurons.
iScience 2024 27(6) 109910
[ PubMed ID = 38783998 ] [ RRC reference ]

Weng JW, Park H, Valotteau C, Chen RT, Essmann CL, Pujol N, Sternberg PW, Chen CH.
Body stiffness is a mechanical property that facilitates contact-mediated mate recognition in Caenorhabditis elegans.
Curr Biol 2023 33(17) 3585-3596.e5
[ PubMed ID = 37541249 ] [ RRC reference ]

Shi H, Zhao J, Li Y, Li J, Li Y, Zhang J, Qiu Z, Wu C, Qin M, Liu C, Zeng Z, Zhang C, Gao L.
Ginsenosides Rg1 regulate lipid metabolism and temperature adaptation in Caenorhabditis elegans.
J Ginseng Res 2023 47(4) 524-533
[ PubMed ID = 37397410 ] [ RRC reference ]

Zhao L, Wu B, Liang S, Min D, Jiang H.
Insight of Silkworm Pupa Oil Regulating Oxidative Stress and Lipid Metabolism in Caenorhabditis elegans.
Foods 2022 11(24)
[ PubMed ID = 36553826 ] [ RRC reference ]

Casorla-Perez LA, Guennoun R, Cubillas C, Peng B, Kornfeld K, Wang D.
Orsay Virus Infection of Caenorhabditis elegans Is Modulated by Zinc and Dependent on Lipids.
J Virol 2022 96(22) e0121122
[ PubMed ID = 36342299 ] [ RRC reference ]

Qin S, Wang Y, Li L, Liu J, Xiao C, Duan D, Hao W, Qin C, Chen J, Yao L, Zhang R, You J, Zheng JS, Shen E, Wu L.
Early-life vitamin B12 orchestrates lipid peroxidation to ensure reproductive success via SBP-1/SREBP1 in Caenorhabditis elegans.
Cell Rep 2022 40(12) 111381
[ PubMed ID = 36130518 ] [ RRC reference ]