分離済み変異体

tm3153

Allele Nametm3153
BalanceCompleted
OutCrossNot Accepted
Sequence NameT26A5.9
Gene Namedlc-1
Worm BaseAllele Name tm3153 (x1)
Gene Name dlc-1
Sequence T26A5.9
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" lethal or sterile. Dr. Y-C. Wu: Emb, abnormal cell devision. Dr. K. O'Conell: mostly Ste. Dr. E.T. Kipreos: Ste, Prv.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 15520/15521-15693/15694 (173 bp deletion)
ChromosomeIII
Putative gene structurecomplement(join(15372..15549, 15830..15921))
Map position-1.25
BalancerhT2,hT2 [bli-4(e937) let-? qIs48]
Map position of balancer
Sequence of primersIntRev:CCTCCGCATTCCGCATTCAC,IntFwd:AGGATGGGATTTATCCAGAC,ExtRev:TACTCAAGTGCCTCCGAGCT,ExtFwd:GTACACGTAGGATCAGGTCA
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Fielder SM, Kent T, Ling H, Gleason EJ, Kelly WG.
A motor independent requirement for dynein light chain in Caenorhabditis elegans meiotic synapsis.
Genetics 2022 220(1)  
[ PubMed ID = 34788833 ] [ RRC reference ]

Ellenbecker M, Osterli E, Wang X, Day NJ, Baumgarten E, Hickey B, Voronina E.
Dynein Light Chain DLC-1 Facilitates the Function of the Germline Cell Fate Regulator GLD-1 in Caenorhabditis elegans.
Genetics 2019 211(2) 665-681 
[ PubMed ID = 30509955 ] [ RRC reference ]

Day NJ, Ellenbecker M, Voronina E.
Caenorhabditis elegans DLC-1 associates with ribonucleoprotein complexes to promote mRNA regulation.
FEBS Lett 2018 592(22) 3683-3695 
[ PubMed ID = 30264890 ] [ RRC reference ]

Wang X, Olson JR, Rasoloson D, Ellenbecker M, Bailey J, Voronina E.
Dynein light chain DLC-1 promotes localization and function of the PUF protein FBF-2 in germline progenitor cells.
Development 2016 143(24) 4643-4653 
[ PubMed ID = 27864381 ] [ RRC reference ]