分離済み変異体

tm3150

Allele Nametm3150
BalanceNot Required
OutCrossNot Accepted
Sequence NameY47G6A.27
Gene NameY47G6A.27
Worm BaseAllele Name tm3150
Gene Name Y47G6A.27
Sequence Y47G6A.27
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 123359/123360-123574/123575 (215 bp deletion)
ChromosomeI
Putative gene structurejoin(122988..123140, 123192..123292, 123342..123670, 124022..124403, 124448..124580, 124640..124807)
Map position-3.2
Balancer
Map position of balancer
Sequence of primersExtRev:GTATTCCCAGCACGACCTGA,IntRev:GGTCCGCTTCTCCTCCTTTA,ExtFwd:TTGTACGAGTATCGTGGACT,IntFwd:CGAGTATCGTGGACTTATCG
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Sharmin R, Elkhalil A, Pena S, Gaddipati P, Clark G, Shah PK, Pellegrino MW, Shaham S, Ghose P.
Mitochondria transported by Kinesin-3 prevent localized calcium spiking to inhibit caspase-dependent specialized cell death.
Curr Biol 2025 35(20) 4932-4945.e4 
[ PubMed ID = 40975051 ] [ RRC reference ]

Sure GR, Chatterjee A, Mishra N, Sabharwal V, Devireddy S, Awasthi A, Mohan S, Koushika SP.
UNC-16/JIP3 and UNC-76/FEZ1 limit the density of mitochondria in C. elegans neurons by maintaining the balance of anterograde and retrograde mitochondrial transport.
Sci Rep 2018 8(1) 8938 
[ PubMed ID = 29895958 ] [ RRC reference ]

Xu S, Wang Z, Kim KW, Jin Y, Chisholm AD.
Targeted Mutagenesis of Duplicated Genes in Caenorhabditis elegans Using CRISPR-Cas9.
J Genet Genomics 2016 43(2) 103-6 
[ PubMed ID = 26924693 ] [ RRC reference ]