分離済み変異体

tm3148

Allele Nametm3148
Allele Type通常株
Sequence NameF56A3.1
Gene Namefncm-1
Worm BaseAllele Name tm3148
Gene Name fncm-1
Sequence F56A3.1
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable. Dr. H-S. Koo: the germ cells are hypersensitive to interstrand DNA crosslinking.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 19258/19259-19768/19769 (510 bp deletion)
ChromosomeI
Putative gene structurejoin(19119..19426, 19498..19585, 19635..19744, 19791..20091, 20585..20727, 20772..21211, 21260..21435, 21637..21816, 21866..21954, 22000..22125, 22521..22626, 22887..22985, 23034..23137, 24012..24093)
Map position-0.29
Balancer
Map position of balancer
Sequence of primersExtFwd:CTGTGCAAGTTGACGTGCAG,IntFwd:CGTATTTCGGCGCCTCACTC,ExtRev:ATCGAAGCTGTACGACGAGA,IntRev:TCTTGCGTGCTCATCGGGTT
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Ye FB, Hamza A, Singh T, Flibotte S, Hieter P, O'Neil NJ.
A Multimodal Genotoxic Anticancer Drug Characterized by Pharmacogenetic Analysis in Caenorhabditis elegans.
Genetics 2020 215(3) 609-621 
[ PubMed ID = 32414869 ] [ RRC reference ]

Kim HM, Beese-Sims SE, Colaiácovo MP.
Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 Are Required for Maintaining Histone Methylation Levels and Interact with the Histone Demethylase LSD1/SPR-5 in Caenorhabditis elegans.
Genetics 2018 209(2) 409-423 
[ PubMed ID = 29588287 ] [ RRC reference ]

Lee KY, Chung KY, Koo HS.
The involvement of FANCM, FANCI, and checkpoint proteins in the interstrand DNA crosslink repair pathway is conserved in C. elegans.
DNA Repair (Amst) 2010 9(4) 374-82 
[ PubMed ID = 20075016 ] [ RRC reference ]