分離済み変異体

tm3126

Allele Nametm3126
BalanceNot Required
OutCrossNot Accepted
Sequence NameW03H9.4
Gene Namecacn-1
Worm BaseAllele Name tm3126
Gene Name cacn-1
Sequence W03H9.4
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable. Dr. E. Cram: 5% of adults have DTC migration defect and 1% are variably abonormal.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 83/84-245/246 (162 bp deletion)
ChromosomeII
Putative gene structurecomplement(join(29517..30017, 31189..31570, 32474..32931, 36350..36549, 37488..[W03H9]112, 200..547, 600..644))
Map position22.45
Balancer
Map position of balancer
Sequence of primersExtFwd:TCGGGAATTTTCGCCGTATG,IntFwd:CGCCGTATGTGGATTCTCGT,IntRev:CGGCTTGCCGAGCAAAGATC,ExtRev:AGAGATCGCCTTCAACGTCC
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Mazzetto M, Gonzalez LE, Sanchez N, Reinke V.
Characterization of the distribution and dynamics of chromatin states in the C. elegans germline reveals substantial H3K4me3 remodeling during oogenesis.
Genome Res 2024 34(1) 57-69 
[ PubMed ID = 38164610 ] [ RRC reference ]

Cha DS, Hollis SE, Datla US, Lee S, Ryu J, Jung HR, Kim E, Kim K, Lee M, Li C, Lee MH.
Differential subcellular localization of DNA topoisomerase-1 isoforms and their roles during Caenorhabditis elegans development.
Gene Expr Patterns 2012 12(5-6) 189-95 
[ PubMed ID = 22452997 ] [ RRC reference ]

Matus DQ, Li XY, Durbin S, Agarwal D, Chi Q, Weiss SJ, Sherwood DR.
In vivo identification of regulators of cell invasion across basement membranes.
Sci Signal 2010 3(120) ra35 
[ PubMed ID = 20442418 ] [ RRC reference ]

Tannoury H, Rodriguez V, Kovacevic I, Ibourk M, Lee M, Cram EJ.
CACN-1/Cactin interacts genetically with MIG-2 GTPase signaling to control distal tip cell migration in C. elegans.
Dev Biol 2010 341(1) 176-85 
[ PubMed ID = 20188721 ] [ RRC reference ]