Home > 分離済み変異体 > tm3118

分離済み変異体

Allele Name		tm3118
Allele Type		通常株
Sequence Name		D2021.1
Gene Name		D2021.1
Worm Base	Allele Name	tm3118
	Gene Name	D2021.1
	Sequence	D2021.1
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		lethal or sterile. Dr. R.H. Horvitz, Dr. A. Salcini: Mel, homozygous mothers lay lethal progeny (embryonic or L1).
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		17360/17361-17907/17908 (547 bp deletion)
Chromosome		X
Putative gene structure		join(13888..13923, 13976..14052, 14106..14432, 14482..14602, 14935..15075, 15130..15402, 15519..15638, 15783..15915, 16607..16791, 16839..17159, 17492..18364, 18420..19009, 19058..19246, 19431..19551)
Map position		0.12
Balancer
Map position of balancer
Sequence of primers		ExtFwd:GCCGCCAGTGTTGCTTCTAA,IntFwd:GAGTAGACGCAATGAGCCTA,ExtRev:ATCGGCAACCATTCTCAGGA,IntRev:CTTAGGCTACTCACCTAATC
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Zaghet N, Madsen K, Rossi F, Perez DF, Amendola PG, Demharter S, Pfisterer U, Khodosevich K, Pasini D, Salcini AE. Coordinated maintenance of H3K36/K27 methylation by histone demethylases preserves germ cell identity and immortality. Cell Rep 2021 37(8) 110050  [ PubMed ID = 34818537 ] [ RRC reference ] Guillermo ARR, Chocian K, Gavriilidis G, Vandamme J, Salcini AE, Mellor J, Woollard A. H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner. BMC Biol 2021 19(1) 59  [ PubMed ID = 33766022 ] [ RRC reference ] Maures TJ, Greer EL, Hauswirth AG, Brunet A. The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner. Aging Cell 2011 10(6) 980-90  [ PubMed ID = 21834846 ] [ RRC reference ] Jin C, Li J, Green CD, Yu X, Tang X, Han D, Xian B, Wang D, Huang X, Cao X, Yan Z, Hou L, Liu J, Shukeir N, Khaitovich P, Chen CD, Zhang H, Jenuwein T, Han JD. Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. Cell Metab 2011 14(2) 161-72  [ PubMed ID = 21803287 ] [ RRC reference ]