Home > 分離済み変異体 > tm3081

分離済み変異体

Allele Name		tm3081
Balance		Not Required
OutCross		Not Accepted
Sequence Name		W02D3.10
Gene Name		W02D3.10
Worm Base	Allele Name	tm3081
	Gene Name	W02D3.10
	Sequence	W02D3.10
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr. H-S. Koo: the germ cells are hypersensitive to interstrand DNA crosslinking.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		31373/31374-32250/32251 (877 bp deletion)
Chromosome		I
Putative gene structure		complement(join(26780..26842, 27725..27860, 27957..28048, 28529..28828, 28881..29038, 29087..29365, 29411..29630, 29916..30144, 30269..30800, 30844..31405, 31497..32084, 32136..32213, 32296..32757, 32808..33245, 33288..33464))
Map position		1.31
Balancer
Map position of balancer
Sequence of primers		ExtFwd:CACTGGTTGCCAGAGGCATC,IntFwd:GTGATCAAACTGTCCACCTC,ExtRev:AGTCATCCTTGGAACGGCTC,IntRev:ATGATCGTGGAGGCCGAATG
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Verschuren J, van Schendel R, van Bostelen I, Verkennis AEE, Knipscheer P, Tijsterman M. FAN1-mediated translesion synthesis and POLQ/HELQ-mediated end joining generate interstrand crosslink-induced mutations. Nat Commun 2025 16(1) 2495  [ PubMed ID = 40082407 ] [ RRC reference ] Germoglio M, Valenti A, Gallo I, Forenza C, Santonicola P, Silva N, Adamo A. In vivo analysis of FANCD2 recruitment at meiotic DNA breaks in Caenorhabditis elegans. Sci Rep 2020 10(1) 103  [ PubMed ID = 31919410 ] [ RRC reference ] Lee KY, Chung KY, Koo HS. The involvement of FANCM, FANCI, and checkpoint proteins in the interstrand DNA crosslink repair pathway is conserved in C. elegans. DNA Repair (Amst) 2010 9(4) 374-82  [ PubMed ID = 20075016 ] [ RRC reference ] Youds JL, Barber LJ, Boulton SJ. C. elegans: a model of Fanconi anemia and ICL repair. Mutat Res 2009 668(1-2) 103-16  [ PubMed ID = 19059419 ] [ RRC reference ]