分離済み変異体

tm3077

Allele Name

tm3077

Balance

Not Required

OutCross

Not Accepted

Sequence Name

Y73B6BL.7

Gene Name

csp-2

Worm Base

Allele Name

tm3077

Gene Name

csp-2

Sequence

Y73B6BL.7

Phenotype

homozygous viable.

Mutation site

28927/28928-29244/29245 (317 bp deletion)

Chromosome

Putative gene structure

join(21611..21668, 21717..21761, 23028..23173, 23521..23670, 23772..23958, 24486..25184, 25323..25400, 25454..25522, 25838..25948, 26210..26320, 28295..28545, 28591..28792, 28840..28934, 28979..29215, 29258..29299)

Map position

3.15

Balancer

Map position of balancer

Sequence of primers

IntRev:CACGTCATTTCTAGACGTCG,ExtRev:ATACTGATCACCGAGGCCAT,ExtFwd:GCCGGGCTATCATAATTAAC,IntFwd:ACGTTTGGGATATCAGTCGA

Distributed lab

Depositor

Dr. S. Mitani

References

Please submit your publication

Flowers S, Kothari R, Torres Cleuren YN, Alcorn MR, Ewe CK, Alok G, Fiallo SL, Joshi PM, Rothman JH.
Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways.
Elife 2023 12
[ PubMed ID = 37782016 ] [ RRC reference ]

Jeong PY, Kumar A, Joshi PM, Rothman JH.
Intertwined Functions of Separase and Caspase in Cell Division and Programmed Cell Death.
Sci Rep 2020 10(1) 6159
[ PubMed ID = 32273538 ] [ RRC reference ]

Wang H, Lu Q, Cheng S, Wang X, Zhang H.
Autophagy activity contributes to programmed cell death in Caenorhabditis elegans.
Autophagy 2013 9(12) 1975-82
[ PubMed ID = 24185352 ] [ RRC reference ]

Huang CY, Chen JY, Wu SC, Tan CH, Tzeng RY, Lu PJ, Wu YF, Chen RH, Wu YC.
C. elegans EIF-3.K promotes programmed cell death through CED-3 caspase.
PLoS One 2012 7(5) e36584
[ PubMed ID = 22590572 ] [ RRC reference ]

Geng X, Zhou QH, Kage-Nakadai E, Shi Y, Yan N, Mitani S, Xue D.
Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells.
Cell Death Differ 2009 16(10) 1385-94
[ PubMed ID = 19575016 ] [ RRC reference ]